Environmental Geochemistry and Health ( IF 3.2 ) Pub Date : 2021-08-14 , DOI: 10.1007/s10653-021-01065-z Ata Rafiee 1 , Juana Maria Delgado-Saborit 2, 3, 4, 5 , Noel J Aquilina 6 , Hoda Amiri 7 , Mohammad Hoseini 8
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Abstract
Concentrations of metals and metalloids derived mainly from anthropogenic activities have increased considerably in the environment. Metals might be associated with increase reactive oxygen species (ROS) damage, potentially related to several health outcomes. This study has recruited 200 adult participants, including 110 males and 90 females in Shiraz (Iran), to investigate the relationship between chronic exposure to metals and ROS damage by analyzing malondialdehyde (MDA) and 8-Oxo-2'-deoxyguanosine (8-OHdG) concentrations, and has evaluated the associations between chronic metal exposure and ROS damage using regression analysis. Our findings showed participants are chronically exposed to elevate As, Ni, Hg, and Pb levels. The mean urinary concentrations of 8-OHdG and MDA were 3.8 ± 2.35 and 214 ± 134 µg/g creatinine, respectively. This study shows that most heavy metals are correlated with urinary ROS biomarkers (R ranges 0.19 to 0.64). In addition, regression analysis accounting for other confounding factors such as sex, age, smoking status, and teeth filling with amalgam highlights that Al, Cu, Si and Sn are associated with 8-OHdG concentrations, while an association between Cr and MDA and 8-OHdG is suggested. Smoking cigarettes and water-pipe is considered a significant contributory factor for both ROS biomarkers (MDA and 8-OHdG).
Graphic abstract
中文翻译：
评估中东人群因环境暴露于金属（Oids）引起的氧化应激
摘要
主要来自人为活动的金属和准金属的浓度在环境中显着增加。金属可能与增加活性氧 (ROS) 损伤有关，这可能与几种健康结果有关。本研究在设拉子（伊朗）招募了 200 名成年参与者，包括 110 名男性和 90 名女性，通过分析丙二醛 (MDA) 和 8-Oxo-2'-deoxyguanosine (8- OHdG) 浓度，并使用回归分析评估了慢性金属暴露与 ROS 损伤之间的关联。我们的研究结果表明，参与者长期暴露于升高的 As、Ni、Hg 和 Pb 水平。8-OHdG 和 MDA 的平均尿浓度分别为 3.8 ± 2.35 和 214 ± 134 µg/g 肌酐。R范围为 0.19 至 0.64）。此外，考虑到性别、年龄、吸烟状况和用汞合金填充牙齿等其他混杂因素的回归分析强调，Al、Cu、Si 和 Sn 与 8-OHdG 浓度相关，而 Cr 和 MDA 与 8建议使用-OHdG。吸烟和水烟被认为是两种 ROS 生物标志物（MDA 和 8-OHdG）的重要促成因素。
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