Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways,FEBS Open Bio

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Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-08-14 , DOI: 10.1002/2211-5463.13272
Noriko Suzuki-Kemuriyama ₁ , Akari Abe ₂ , Sae Nakane ₂ , Kinuko Uno ₃ , Shuji Ogawa ₃ , Atsushi Watanabe ₂ , Ryuhei Sano ₂ , Megumi Yuki ₂ , Katsuhiro Miyajima _{1,

2} , Dai Nakae _{1,

2}

Affiliation

Nonalcoholic steatohepatitis (NASH) is often associated with obesity, but some patients develop NASH without obesity. The physiological processes by which nonobese patients develop NASH and cirrhosis have not yet been determined. Here, we analyzed the effects of dietary methionine content on NASH induced in mice fed on a choline-deficient, methionine-lowered, l-amino acid-defined high-fat diet (CDAHFD). CDAHFD with insufficient methionine induced insulin sensitivity and enhanced NASH pathology, but without obesity. In contrast, CDAHFD with sufficient methionine induced steatosis, and unlike CDAHFD with insufficient methionine, also induced obesity and insulin resistance. Gene profile analysis revealed that the disease severity in CDAHFD may partially be due to upregulation of the Rho family GTPases pathway and mitochondrial and nuclear receptor signal dysfunction. The signaling factors/pathways detected in this study may assist in future study of NASH regulation, especially its ‘nonobese’ subtype.

中文翻译：

以缺乏胆碱、L-氨基酸确定的高脂肪饮食喂养的患有非酒精性脂肪性肝炎的非肥胖小鼠表现出信号通路的改变

非酒精性脂肪性肝炎 (NASH) 通常与肥胖有关，但有些患者会发展为 NASH 而没有肥胖。非肥胖患者发生 NASH 和肝硬化的生理过程尚未确定。在这里，我们分析了饮食中蛋氨酸含量对喂食胆碱缺乏、蛋氨酸降低的小鼠诱导的 NASH 的影响。-氨基酸定义的高脂肪饮食（CDAHFD）。蛋氨酸不足的 CDAHFD 诱导胰岛素敏感性和增强 NASH 病理学，但没有肥胖。相反，蛋氨酸充足的CDAHFD会诱发脂肪变性，而与蛋氨酸不足的CDAHFD不同，CDAHFD也会诱发肥胖和胰岛素抵抗。基因谱分析显示，CDAHFD 的疾病严重程度可能部分是由于 Rho 家族 GTP 酶通路的上调以及线粒体和核受体信号功能障碍。本研究中检测到的信号因子/通路可能有助于未来对 NASH 调控的研究，尤其是其“非肥胖”亚型。

更新日期：2021-08-14

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