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The effect of SARS-CoV-2 on the nervous system: a review of neurological impacts caused by human coronaviruses
Reviews in the Neurosciences ( IF 3.4 ) Pub Date : 2021-08-13 , DOI: 10.1515/revneuro-2021-0041
Colin Day 1, 2 , Carson Studders 2, 3 , Kim Arklie 2, 3 , Asees Kaur 2, 3 , Kyra Teetzen 1, 2 , Rebecca Kirsch 4 , Laila Abelseth 2 , Ian Fraser 3 , Emily Abelseth 1 , Stephanie M Willerth 2, 3, 5
Affiliation  

The COVID-19 pandemic has affected millions of people worldwide. While coronaviruses typically have low rates of neurotropic effects, the massive transmission of SARS-CoV-2 suggests that a substantial population will suffer from potential SARS-CoV-2-related neurological disorders. The rapid and recent emergence of SARS-CoV-2 means little research exists on its potential neurological effects. Here we analyze the effects of similar viruses to provide insight into the potential effects of SARS-CoV-2 on the nervous system and beyond. Seven coronavirus strains (HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) can infect humans. Many of these strains cause neurological effects, such as headaches, dizziness, strokes, seizures, and critical illness polyneuropathy/myopathy. Certain studies have also linked coronaviruses with multiple sclerosis and extensive central nervous system injuries. Reviewing these studies provides insight into the anticipated effects for patients with SARS-CoV-2. This review will first describe the effects of other coronaviruses that have caused severe disease (SARS-CoV, MERS-CoV) on the nervous system, as well as their proposed origins, non-neurological effects, and neurological infection mechanisms. It will then discuss what is known about SARS-CoV-2 in these areas with reference to the aforementioned viruses, with the goal of providing a holistic picture of SARS-CoV-2.

中文翻译:

SARS-CoV-2 对神经系统的影响:人类冠状病毒引起的神经系统影响综述

COVID-19 大流行已影响全球数百万人。虽然冠状病毒通常具有较低的嗜神经效应,但 SARS-CoV-2 的大规模传播表明,大量人群将患有潜在的 SARS-CoV-2 相关神经系统疾病。SARS-CoV-2 的迅速出现和最近的出现意味着对其潜在的神经系统影响几乎没有研究。在这里,我们分析了类似病毒的影响,以深入了解 SARS-CoV-2 对神经系统及其他系统的潜在影响。七种冠状病毒株(HCoV-OC43、HCoV-HKU1、HCoV-229E、HCoV-NL63、SARS-CoV、MERS-CoV、SARS-CoV-2)可以感染人类。其中许多菌株会引起神经系统影响,例如头痛、头晕、中风、癫痫发作和危重病多发性神经病/肌病。某些研究还将冠状病毒与多发性硬化症和广泛的中枢神经系统损伤联系起来。回顾这些研究可以深入了解对 SARS-CoV-2 患者的预期影响。这篇综述将首先描述导致严重疾病的其他冠状病毒(SARS-CoV、MERS-CoV)对神经系统的影响,以及它们提出的起源、非神经系统影响和神经系统感染机制。然后,它将参考上述病毒讨论这些领域对 SARS-CoV-2 的了解,目的是提供 SARS-CoV-2 的整体图景。这篇综述将首先描述导致严重疾病的其他冠状病毒(SARS-CoV、MERS-CoV)对神经系统的影响,以及它们提出的起源、非神经系统影响和神经系统感染机制。然后,它将参考上述病毒讨论这些领域对 SARS-CoV-2 的了解,目的是提供 SARS-CoV-2 的整体图景。这篇综述将首先描述导致严重疾病的其他冠状病毒(SARS-CoV、MERS-CoV)对神经系统的影响,以及它们提出的起源、非神经系统影响和神经系统感染机制。然后,它将参考上述病毒讨论这些领域对 SARS-CoV-2 的了解,目的是提供 SARS-CoV-2 的整体图景。
更新日期:2021-08-13
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