The signal transducer and activator of transcription 6 (STAT6) is implicated in the pathogenesis of some lymphomas including primary central nervous system lymphomas (PCNSLs). The aim of this study was to investigate STAT6 expression and clinicopathologic features in 25 PCNSLs using immunohistochemistry with 2 different anti-STAT6 antibodies. One (YE361) recognizes the C-terminus domain of the STAT6 protein and the other (Y641) recognizes the phosphorylated form of the protein. The phosphorylated STAT6 form was not expressed in any of the cases studied whereas the YE361 STAT6 showed only cytoplasmic expression in 14 (56%) cases. This expression did not correlate with age, prognostic score, multiplicity, invasion of deep structures, response to treatment, disease recurrence, overall survival, or BCL6, BCL2, PD-L1, and CD8 expression. A STAT6 expression score showed a trend for correlating with clinical performance status. It also showed a positive correlation with MYC expression. Thus, the phosphorylated form of STAT6 was not found in the current series, while the YE361 STAT6 showed only cytoplasmic expression and was associated with expression of MYC.

中文翻译：

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原发性中枢神经系统淋巴瘤中 STAT6 和磷酸化 STAT6 的表达

信号转导和转录激活因子 6 (STAT6) 与一些淋巴瘤的发病机制有关，包括原发性中枢神经系统淋巴瘤 (PCNSL)。本研究的目的是使用免疫组织化学和 2 种不同的抗 STAT6 抗体来研究 25 例 PCNSL 中 STAT6 的表达和临床病理学特征。一个 (YE361) 识别 STAT6 蛋白的 C 末端结构域，另一个 (Y641) 识别蛋白质的磷酸化形式。磷酸化的 STAT6 形式在所研究的任何病例中均未表达，而 YE361 STAT6 在 14 (56%) 个病例中仅显示细胞质表达。这种表达与年龄、预后评分、多重性、深层结构的侵袭、对治疗的反应、疾病复发、总生存期或 BCL6、BCL2、PD-L1 和 CD8 表达无关。STAT6 表达评分显示出与临床表现状态相关的趋势。它还与MYC表达呈正相关。因此，在当前系列中未发现 STAT6 的磷酸化形式，而 YE361 STAT6 仅显示细胞质表达并与 MYC 的表达相关。