INTRODUCTION High-resolution manometry (HRM) is generally considered the primary method to evaluate esophageal motility; functional luminal imaging probe (FLIP) panometry represents a novel method to do so and is completed during sedated endoscopy. This study aimed to compare HRM and FLIP panometry in predicting esophageal retention on timed barium esophagram (TBE). METHODS A total of 329 adult patients who completed FLIP, HRM, and TBE for primary esophageal motility evaluation were included. An abnormal TBE was defined by a 1-minute column height >5 cm or impaction of a 12.5-mm barium tablet. The integrated relaxation pressure (IRP) on HRM was assessed in the supine and upright patient positions. Esophagogastric junction (EGJ) opening was evaluated with 16-cm FLIP performed during sedated endoscopy through EGJ-distensibility index and maximum EGJ diameter. RESULTS Receiver operating characteristic curves to identify an abnormal TBE demonstrated AUC (95% confidence interval) of 0.79 (0.75-0.84) for supine IRP, 0.79 (0.76-0.86) for upright IRP, 0.84 (0.79-0.88) for EGJ-distensibility index, and 0.88 (0.85-0.92) for maximum EGJ diameter. Logistic regression to predict abnormal TBE showed odds ratios (95% confidence interval) of 1.8 (0.84-3.7) for consistent IRP elevation and 39.7 (16.4-96.2) for reduced EGJ opening on FLIP panometry. Of 40 patients with HRM-FLIP panometry discordance, HRM-IRP was consistent with TBE in 23% while FLIP panometry was consistent with TBE in 78%. DISCUSSION FLIP panometry provided superior detection of esophageal retention over IRP on HRM. However, application of a complementary evaluation involving FLIP panometry, HRM, and TBE may be necessary to accurately diagnose esophageal motility disorders.

中文翻译：

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食管滞留的预测：高分辨率测压法和功能性管腔成像探头全景测量法的比较研究。

简介 高分辨率测压法 (HRM) 通常被认为是评估食管运动的主要方法；功能性管腔成像探针（FLIP）全景测量代表了一种新颖的方法，并在镇静内窥镜检查期间完成。本研究旨在比较 HRM 和 FLIP 全景测量法在预测定时食管钡餐造影 (TBE) 上食管滞留方面的效果。方法 共有 329 名完成 FLIP、HRM 和 TBE 进行初级食管动力评估的成年患者纳入研究。异常 TBE 的定义是 1 分钟柱高 >5 厘米或 12.5 毫米钡片的撞击。在患者仰卧位和直立位时评估 HRM 的综合松弛压力 (IRP)。通过 EGJ 扩张指数和最大 EGJ 直径，在镇静内窥镜检查期间使用 16 厘米 FLIP 评估食管胃连接部 (EGJ) 开口。结果 识别异常 TBE 的受试者工作特征曲线显示，仰卧位 IRP 的 AUC（95% 置信区间）为 0.79 (0.75-0.84)，直立 IRP 为 0.79 (0.76-0.86)，EGJ 扩张指数为 0.84 (0.79-0.88) ，最大 EGJ 直径为 0.88 (0.85-0.92)。预测异常 TBE 的 Logistic 回归显示，在 FLIP 全景测量中，IRP 一致升高的比值比（95% 置信区间）为 1.8 (0.84-3.7)，而 EGJ 开口减少的比值比为 39.7 (16.4-96.2)。在 40 名 HRM-FLIP 全景测量不一致的患者中，23% 的 HRM-IRP 与 TBE 一致，而 78% 的 FLIP 全景测量与 TBE 一致。讨论 FLIP 全景测量法在 HRM 上比 IRP 更能检测食管滞留。然而，为了准确诊断食管动力障碍，可能需要应用涉及 FLIP 全景测量、HRM 和 TBE 的补充评估。