To develop a LRP1B gene mutation based prognostic model for hepatocellular carcinoma (HCC) patients risk prediction. Methods: The LRP1B gene mutation rate was calculated from HCC patient samples. Meanwhile, differentially expressed genes according to LRP1B mutant were screened out for prognostic model establishment. Based on this innovative model, HCC patients were categoried into high and low-risk group. The immune status including immune cell infiltration ratio and checkpoints have been explored in two groups. The functions of LRP1B and risk factors in the model were verified using both in vivo and in vitro experiments.

中文翻译：

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肝细胞癌 LRP1B 突变相关预后模型的开发和验证。

开发基于 LRP1B 基因突变的肝细胞癌 (HCC) 患者风险预测预后模型。方法：从 HCC 患者样本中计算 LRP1B 基因突变率。同时，筛选出根据LRP1B突变体的差异表达基因用于预后模型的建立。基于这一创新模型，将HCC患者分为高危组和低危组。研究了两组免疫状态，包括免疫细胞浸润率和检查点。通过体内和体外实验验证了模型中 LRP1B 的功能和风险因素。