To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–associated death.

We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records.

We included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5–19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition; obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/or ethnicity to decedents without MIS-C; 11 of 16 (69%) had at least 1 underlying condition.

SARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.

描述 <21 岁严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 相关死亡患者的人口统计学、临床特征和住院病程。

我们于 2020 年 2 月 12 日至 7 月 31 日期间对美国 <21 岁人群中疑似 SARS-CoV-2 相关死亡进行了回顾性病例系列研究。所有州和地区均受邀参与。我们从医疗记录中提取了人口统计和临床数据，包括实验室和治疗详细信息。

我们纳入了来自 25 个参与辖区的 112 例 SARS-CoV-2 相关死亡病例。中位年龄为 17 岁（IQR 8.5-19 岁）。大多数死者为男性（71 人，63%），31 人（28%）为黑人（非西班牙裔），52 人（46%）为西班牙裔。 96 名死者 (86%) 患有至少 1 种潜在疾病；最常见的是肥胖（42%）、哮喘（29%）和发育障碍（22%）。在 69 名住院死者中，常见并发症包括机械通气（75%）和急性呼吸衰竭（82%）。符合儿童多系统炎症综合征 (MIS-C) 标准的 16 名 (14%) 死者在年龄、性别、种族和/或民族方面与没有 MIS-C 的死者相似； 16 人中有 11 人 (69%) 至少患有 1 种潜在疾病。

<21 岁人群中与 SARS-CoV-2 相关的死亡主要发生在黑人（非西班牙裔）和西班牙裔、男性患者和年龄较大的青少年中。最常见的潜在疾病是肥胖、哮喘和发育障碍。患有 2019 年冠状病毒病的死者比患有 MIS-C 的死者更有可能患有基础疾病。