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Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
Molecular and Cellular Endocrinology ( IF 3.8 ) Pub Date : 2021-08-13 , DOI: 10.1016/j.mce.2021.111423
Letícia Mattei 1 , Fabiane Valentini Francisqueti-Ferron 1 , Jéssica Leite Garcia 1 , Artur Junio Togneri Ferron 1 , Carol Cristina Vágula de Almeida Silva 1 , Cristina Schmitt Gregolin 1 , Erika Tiemi Nakandakare-Maia 1 , Janaína das Chagas Paixão Silva 2 , Fernando Moreto 1 , Igor Otávio Minatel 2 , Camila Renata Corrêa 1
Affiliation  

Background

Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamma-oryzanol (γOz) is a compound present in the whole grain of rice that presents anti-inflammatory and antioxidant activities. The aim of this study was to verify if the effect antioxidant and anti-inflammatory of yOz attenuate insulin resistance in skeletal muscle of obese rats by increasing GLUT- 4 expression.

Methods

Male Wistar rats (±187 g) were initially randomly distributed into 2 experimental groups (control, n = 6, and high sugar-fat diet (HSF), n = 12) for 20 weeks. At week 20th of this study, once obesity and insulin resistance were detected in the HSF group, animals were divided to begin the treatment with γOz or continue receiving HSF for 10 more weeks. At the end it was analyzed nutritional, metabolic, inflammatory and oxidative stress parameters and GLUT-4 protein expression.

Results

The treatment improved insulin resistance, reduced inflammation, increased antioxidant response and GLUT-4 expression.

Conclusion

It is possible to conclude that the antioxidant and anti-inflammatory activity of yOz attenuates insulin resistance by increasing GLUT-4 expression in skeletal muscle of obese animals.



中文翻译:


γ-谷维素的抗氧化和抗炎特性可通过增加肥胖动物骨骼肌中 GLUT-4 的表达来减弱胰岛素抵抗


 背景


骨骼肌是全身葡萄糖稳态最重要的器官。然而,有人认为,肥胖相关炎症可能通过多种机制参与胰岛素抵抗和 2 型糖尿病 (DM2) 的发展,其中包括 4 型葡萄糖转运蛋白 (GLUT-4) 表达的减少。 γ-谷维素 (γOz) 是一种存在于全米中的化合物,具有抗炎和抗氧化活性。本研究的目的是验证 yOz 的抗氧化和抗炎作用是否通过增加 GLUT-4 表达来减轻肥胖大鼠骨骼肌的胰岛素抵抗。

 方法


雄性 Wistar 大鼠(±187 g)最初被随机分为 2 个实验组(对照组,n = 6,高糖脂肪饮食 (HSF),n = 12),为期 20 周。在这项研究的第 20 周,一旦 HSF 组检测到肥胖和胰岛素抵抗,动物就会被分为开始接受 γOz 治疗或继续接受 HSF 10 周以上。最后分析了营养、代谢、炎症和氧化应激参数以及 GLUT-4 蛋白表达。

 结果


该治疗改善了胰岛素抵抗、减少炎症、增加抗氧化反应和 GLUT-4 表达。

 结论


可以得出结论,yOz 的抗氧化和抗炎活性通过增加肥胖动物骨骼肌中 GLUT-4 的表达来减弱胰岛素抵抗。

更新日期:2021-08-17
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