APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network,CNS Neuroscience & Therapeutics

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APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2021-08-12 , DOI: 10.1111/cns.13716
Feifei Zang ₁ , Yao Zhu ₁ , Qianqian Zhang ₁ , Chang Tan ₁ , Qing Wang ₁ , Chunming Xie _{1,

2} ,

Affiliation

This study aims to investigate the mechanisms by which apolipoprotein E (APOE) genotype modulates the relationship between low-density lipoprotein receptor-related protein 1 (LRP1) rs1799986 variant on the default mode network (DMN) and cognition in Alzheimer's disease (AD) spectrum populations.

中文翻译：

APOE 基因型通过扰乱默认模式网络调节 LRP1 多态性与阿尔茨海默病谱系认知之间的关系

本研究旨在探讨载脂蛋白 E ( APOE ) 基因型调节默认模式网络 (DMN) 上的低密度脂蛋白受体相关蛋白 1 ( LRP1 ) rs1799986 变体与阿尔茨海默病 (AD) 谱系认知之间关系的机制人口。

更新日期：2021-10-11

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