当前位置: X-MOL 学术Tuberculosis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
LIODetect®TB-ST: Evaluation of novel blood test for a rapid diagnosis of active pulmonary and extra-pulmonary tuberculosis in IGRA confirmed patients
Tuberculosis ( IF 2.8 ) Pub Date : 2021-08-13 , DOI: 10.1016/j.tube.2021.102119
Marco Pio La Manna 1 , Bartolo Tamburini 1 , Valentina Orlando 1 , Giusto Davide Badami 1 , Paola Di Carlo 2 , Antonio Cascio 2 , Mahavir Singh 3 , Francesco Dieli 1 , Nadia Caccamo 1
Affiliation  

Because of the current limits of immunological tests in the diagnosis of tuberculosis there is a need to identify new and rapid tests that can be carried out on a large scale in endemic countries and useful in the identification of infected subjects, but also able to discriminate those with latent infection from subjects with active. We have taken into consideration and analysed the LIODetect®TB-ST Tuberculosis Rapid Test, a membrane test for the qualitative detection of specific IgG, IgA, and IgM antibodies against Mycobacterium tuberculosis, performed on serum, plasma, or whole blood.85 samples positive to QuantiFERON TB-GOLD PLUS test were processed using this test and the results obtained were concordant with clinical diagnosis.To our knowledge, the LIODetect®TB-ST Tuberculosis Rapid Test is the only test; that identifies active tuberculosis disease with high sensitivity and specificity and its use might be of help in the diagnosis of tuberculosis, especially in endemic countries.



中文翻译:

LIODetect®TB-ST:评估新型血液检测,用于快速诊断 IGRA 确诊患者的活动性肺结核和肺外结核

由于目前在结核病诊断中免疫学检测的局限性,需要确定新的快速检测方法,这些检测方法可以在流行国家大规模进行,有助于识别受感染的受试者,但也能够区分那些来自活跃的受试者的潜伏感染。我们考虑并分析了 LIODetect®TB-ST 结核病快速检测,这是一种用于定性检测针对结核分枝杆菌的特异性 IgG、IgA 和 IgM 抗体的膜检测,对血清、血浆或全血进行。使用该测试处理了对 QuantiFERON TB-GOLD PLUS 测试呈阳性的 85 个样本,获得的结果与临床诊断一致。据我们所知,LIODetect®TB-ST 结核病快速测试是唯一的测试;以高敏感性和特异性识别活动性结核病及其使用可能有助于诊断结核病,特别是在流行国家。

更新日期:2021-08-16
down
wechat
bug