Helical Bisphosphinites in Asymmetric Tsuji-Trost Allylation: a Remarkable P:Pd Ratio Effect,ChemCatChem

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Helical Bisphosphinites in Asymmetric Tsuji-Trost Allylation: a Remarkable P:Pd Ratio Effect
ChemCatChem ( IF 3.8 ) Pub Date : 2021-08-13 , DOI: 10.1002/cctc.202101072
Marion Barbazanges ₁ , Caleb Medena ₂ , Corinne Aubert ₃ , Etienne Derat ₄ , Louis Fensterbank ₄ , Geoffrey Gontard ₄ , Omar Khaled ₄ , Cyril Ollivier ₄ , Nicolas Vanthuyne ₅ , Marc Petit ₄

Affiliation

It's all about the ratio: A remarkable effect of the ligand to metal ratio in the palladium-catalyzed Tsuji-Trost allylation is revealed here. By changing the amount of chiral bisphosphinite-[6]-helicene ligand in the catalytic system, (R) and (S) isomeric products were selectively obtained. ³¹P NMR, X-ray and DFT calculations were used to shed light on this reaction.

中文翻译：

不对称Tsuji-Trost 烯丙基化中的螺旋双膦酸盐：显着的P:Pd 比效应

一切都与比例有关：此处揭示了钯催化的 Tsuji-Trost 烯丙基化中配体与金属比例的显着影响。通过改变催化体系中手性双亚膦酸酯-[6]-螺旋配体的数量，选择性地获得了( R )和( S )异构产物。³¹ P NMR、X-射线和DFT计算用于阐明该反应。

更新日期：2021-08-13

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