Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target,ChemBioChem

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Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target
ChemBioChem ( IF 2.6 ) Pub Date : 2021-08-12 , DOI: 10.1002/cbic.202100314
Nikolas Esposito ₁ , David W Konas ₁ , Nina M Goodey ₁

Affiliation

Indole-3-glycerol phosphate synthase (IGPS) catalyzes the indole-forming step in bacterial tryptophan biosynthesis. This minireview summarizes the data on expression, kinetics, mechanism, and inhibition of IGPS from Mycobacterium tuberculosis. Crystal structures are also analyzed and compared to reveal structure-function relationships of value for the purposes of drug design and biocatalyst engineering.

中文翻译：

结核分枝杆菌的吲哚-3-甘油磷酸合酶：一个潜在的新药物靶点

吲哚-3-甘油磷酸合酶 (IGPS)催化细菌色氨酸生物合成中的吲哚形成步骤。本小型综述总结了结核分枝杆菌IGPS 的表达、动力学、机制和抑制的数据。还对晶体结构进行了分析和比较，以揭示有价值的结构-功能关系，以用于药物设计和生物催化剂工程。

更新日期：2021-08-12

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