Drug-loaded liposomes are typical examples of nanomedicines. We show here that doxorubicin, the anti-cancer agent in the liposomal drug Doxil, can sensitize Ytterbium (Yb³⁺) and generate its near-infrared (NIR) emission. When doxorubicin and amphiphilic Yb³⁺ chelates are incorporated into liposomes, the sensitized emission of Yb³⁺ is dependent on the integrity of the particles, which can be used to monitor drug release. We also established the first demonstration that the NIR Yb³⁺ emission signal is observable in living mice following intratumoral injection of the Yb³⁺-doxorubicin-liposomes, using a commercial macroscopic setup equipped with a NIR camera.

中文翻译：

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近红外发射镱脂质体的多柔比星敏化发光：直接监测药物释放

载药脂质体是纳米药物的典型例子。我们在这里展示了阿霉素，脂质体药物 Doxil 中的抗癌剂，可以使镱 (Yb ³⁺ )敏感并产生其近红外 (NIR) 发射。当阿霉素和两亲性 Yb ³⁺螯合物掺入脂质体时，Yb ³⁺的敏化发射取决于颗粒的完整性，可用于监测药物释放。我们还首次证明，在瘤内注射 Yb ^{3+ -多}柔比星脂质体后，活小鼠中可观察到NIR Yb ³⁺发射信号，使用配备 NIR 相机的商业宏观设置。