Advances in Photocrosslinkable Materials for 3D Bioprinting,Advanced Engineering Materials

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Advances in Photocrosslinkable Materials for 3D Bioprinting
Advanced Engineering Materials ( IF 3.4 ) Pub Date : 2021-08-13 , DOI: 10.1002/adem.202100663
Wen Zhang ₁ , Wenbo Ye ₁ , Yunfeng Yan ₁

Affiliation

3D bioprinting integrating multidisciplinary advances in engineering, cell biology, and material science is able to fabricate artificial tissues and organ-like structures with biology or clinic-relevant size, shape, and structural integrity. Therefore, 3D bioprinting has huge potential in tissue engineering and regenerative medicine. Suitable bioink plays a key role in the modulation of the printing process, the properties, and functions of printed constructs. Herein, the advances in photocrosslinkable biomaterials are focused on, which have been proven as promising types of bioinks for 3D bioprinting. The general strategies of 3D bioprinting and the main mechanisms involved in photocrosslinking are first discussed. Then, the recent advances in photocrosslinkable bioinks including natural protein- and polysaccharide-based materials, synthetic polymers, and decellularized extracellular matrix (dECM)-based materials are highlighted. Finally, the ongoing challenges in the delicate balance between the printability and biological activities of photocrosslinkable biomaterials are discussed and the outlook for this emerging area is analyzed.

中文翻译：

用于 3D 生物打印的光交联材料的进展

结合工程、细胞生物学和材料科学的多学科进展的 3D 生物打印能够制造具有生物学或临床相关尺寸、形状和结构完整性的人造组织和器官样结构。因此，3D生物打印在组织工程和再生医学方面具有巨大的潜力。合适的生物墨水在调节打印过程、打印结构的特性和功能方面发挥着关键作用。本文重点关注可光交联生物材料的进展，这些材料已被证明是用于 3D 生物打印的有前途的生物墨水类型。首先讨论了 3D 生物打印的一般策略和光交联所涉及的主要机制。然后，光交联生物墨水的最新进展，包括天然蛋白质和多糖基材料，突出显示了合成聚合物和基于脱细胞细胞外基质 (dECM) 的材料。最后，讨论了光交联生物材料的可印刷性和生物活性之间微妙平衡所面临的挑战，并分析了这一新兴领域的前景。

更新日期：2021-08-13

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