当前位置: X-MOL 学术Pharmacol. Biochem. Behav. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Psychologically traumatic stress inducing redox – inflammation interplay; which comes first?
Pharmacology Biochemistry and Behavior ( IF 3.3 ) Pub Date : 2021-08-13 , DOI: 10.1016/j.pbb.2021.173254
Evangelos Karanikas 1 , Danai Ioanna Vlasidou 1
Affiliation  

Evidence suggests the involvement of redox and inflammation fields under conditions of psychological trauma. Factors from immunity, Hypothalamic-Adrenal-Pituitary axis, Kynurenine pathway, Dysglycemia, Glutamatergic systems as well as elements from redox mechanisms participate in a highly complex neurobiological process. Yet, little is known about their interplay. There is evidence suggesting a psychologically traumatic stress induced redox-originated inflammatory activation and vice versa. A holistic approach would suggest a parallel activation of the involved mechanisms with highly tight interdependency. The present report aims at collecting the evidence supporting either directionality of the involved mechanisms, finally suggesting a diagram depicting a synthesis of this interplay.



中文翻译:

引起氧化还原的心理创伤性压力 - 炎症相互作用;哪个先出现?

有证据表明,在心理创伤的情况下,氧化还原和炎症场的参与。来自免疫、下丘脑-肾上腺-垂体轴、犬尿氨酸途径、血糖异常、谷氨酸能系统以及氧化还原机制的因素参与了一个高度复杂的神经生物学过程。然而,人们对它们的相互作用知之甚少。有证据表明心理创伤性压力会诱导氧化还原引发的炎症激活,反之亦然。整体方法将建议以高度紧密的相互依赖性并行激活相关机制。本报告旨在收集支持所涉及机制的方向性的证据,最后提出一个描述这种相互作用综合的图表。

更新日期:2021-08-17
down
wechat
bug