Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as an important management dilemma particularly in patients with underlying inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been used as a safe and highly effective treatment option for rCDI refractory to standard antibiotic therapies. The aim of this study was to report the efficacy of FMT in Iranian rCDI patients with concurrent IBD. A total of seven consecutive patients with ulcerative colitis (UC) who had experienced 3 episodes of rCDI were enrolled in this study. All patients received at least a single FMT administered during colonoscopy by direct infusion of minimally processed donor stool. Patients were followed for a minimum of 6 months for assessment of treatment efficacy and adverse events (AEs) attributable to FMT. All 7 UC patients (100%) experienced a durable clinical response to a single FMT following 2 months after the procedure. One patient received a second FMT in which a successful resolution of rCDI was ultimately achieved. No serious AEs from FMT were noted. FMT through colonoscopy was a safe, simple and effective alternative treatment approach for rCDI in patients with underlying IBD. However, its use and efficacy should be pursued in long-term prospective controlled trials.

中文翻译：

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粪便微生物群移植治疗并发溃疡性结肠炎患者复发性艰难梭菌感染。


复发性艰难梭菌感染（rCDI）的治疗已成为一个重要的治疗困境，特别是对于患有潜在炎症性肠病（IBD）的患者。粪便微生物群移植 (FMT) 已被用作标准抗生素治疗难治性 rCDI 的安全且高效的治疗选择。本研究的目的是报告 FMT 对并发 IBD 的伊朗 rCDI 患者的疗效。共有 7 名连续经历过 3 次 rCDI 的溃疡性结肠炎 (UC) 患者纳入本研究。所有患者在结肠镜检查期间至少接受一次 FMT，通过直接输注经过最低限度处理的供体粪便进行。对患者进行至少 6 个月的随访，以评估治疗效果和 FMT 引起的不良事件 (AE)。所有 7 名 UC 患者 (100%) 在手术后 2 个月后对单次 FMT 产生了持久的临床反应。一名患者接受了第二次 FMT，最终成功解决了 rCDI。没有发现 FMT 造成的严重不良事件。通过结肠镜检查进行 FMT 是治疗 IBD 患者 rCDI 的一种安全、简单且有效的替代治疗方法。然而，其用途和功效应在长期前瞻性对照试验中进行探讨。