Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as an important management dilemma particularly in patients with underlying inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been used as a safe and highly effective treatment option for rCDI refractory to standard antibiotic therapies. The aim of this study was to report the efficacy of FMT in Iranian rCDI patients with concurrent IBD. A total of seven consecutive patients with ulcerative colitis (UC) who had experienced 3 episodes of rCDI were enrolled in this study. All patients received at least a single FMT administered during colonoscopy by direct infusion of minimally processed donor stool. Patients were followed for a minimum of 6 months for assessment of treatment efficacy and adverse events (AEs) attributable to FMT. All 7 UC patients (100%) experienced a durable clinical response to a single FMT following 2 months after the procedure. One patient received a second FMT in which a successful resolution of rCDI was ultimately achieved. No serious AEs from FMT were noted. FMT through colonoscopy was a safe, simple and effective alternative treatment approach for rCDI in patients with underlying IBD. However, its use and efficacy should be pursued in long-term prospective controlled trials.

中文翻译：

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粪便微生物群移植治疗并发溃疡性结肠炎患者复发性艰难梭菌感染。

复发性艰难梭菌感染 (rCDI) 的治疗已成为一个重要的管理难题，尤其是在患有潜在炎症性肠病 (IBD) 的患者中。粪便微生物群移植 (FMT) 已被用作对标准抗生素治疗无效的 rCDI 的安全且高效的治疗选择。本研究的目的是报告 FMT 在并发 IBD 的伊朗 rCDI 患者中的疗效。共有 7 名经历过 3 次 rCDI 发作的溃疡性结肠炎 (UC) 连续患者参加了这项研究。所有患者在结肠镜检查期间通过直接输注经过最少处理的供体粪便至少接受一次 FMT。对患者进行至少 6 个月的随访，以评估治疗效果和归因于 FMT 的不良事件 (AE)。手术后 2 个月，所有 7 名 UC 患者 (100%) 都经历了对单一 FMT 的持久临床反应。一名患者接受了第二次 FMT，最终成功解决了 rCDI。没有发现来自 FMT 的严重 AE。通过结肠镜检查进行 FMT 是治疗潜在 IBD 患者 rCDI 的一种安全、简单和有效的替代治疗方法。然而，其使用和疗效应在长期前瞻性对照试验中进行。