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One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors.
Haematologica ( IF 8.2 ) Pub Date : 2021-08-12 , DOI: 10.3324/haematol.2021.279189
Dietger Niederwieser , Helen Baldomero , Nosa Bazuaye , Caitrin Bupp , Naeem Chaudhri , Selim Corbacioglu , Alaa Elhaddad , Cristóbal Frutos , Sebastian Galeano , Nada Hamad , Amir Ali Hamidieh , Shahrukh Hashmi , Aloysius Ho , Mary M. Horowitz , Minako Iida , Gregorio Jaimovich , Amado Karduss , Yoshihisa Kodera , Nicolaus Kröger , Regis Péffault de Latour , Jong Wook Lee , Juliana Martínez-Rolón , Marcelo C. Pasquini , Jakob Passweg , Kristjan Paulson , Adriana Seber , John A. Snowden , Alok Srivastava , Jeff Szer , Daniel Weisdorf , Nina Worel , Mickey B.C. Koh , Mahmoud Aljurf , Hildegard Greinix , Yoshiko Atsuta , Wael Saber

The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCTs were reported from 1662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCTs had been performed by 2019 from 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCTs were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCTs are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated is plateauing and cord blood in decline.

中文翻译:

150 万次造血干细胞移植:通过使用不同的家庭捐赠者,在全球范围内持续和差异化地改善。

全球血液和骨髓移植网络 (WBMT) 追求促进造血细胞移植 (HCT) 的使命,例如通过评估会员协会、国家注册和个人中心的活动。2016 年,来自 195 个世界卫生组织成员国中的 86 个国家的 1662 个 HCT 团队报告了 82,718 例首例 HCT,这意味着自体 HCT 和异体 HCT 的全球增幅分别为 6.2% 和 7.0%,总数达到 1,298,897 个。假设频率为 84,000 次/年,从 1957 年到 2019 年已进行了 150 万次 HCT。据报道,自体 (53.5%) 比异体 HCT 略多,相关 (53.6%) 比非相关 HCT 多。在白血病和淋巴组织增生性疾病的半相合相关 HCT 中注意到显着增加,但在非恶性疾病中甚至更多。移植率(TR;HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋(SEA/WPR)为 53.6,非洲/东地中海为 27.8 (AFR/EMR)。有趣的是,半相合 TR 在 SEA/WPR 中为 32%,在拉丁美洲为 26%,但在欧洲和 EMR 中仅为 14%,在所有同种异体 HCT 中为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲最高 (7.7),其次是北美 (6.0)、SEA/WPR (1.9)、拉丁美洲 (1.6) 和 AFR/EMR (0.4)。与自体活动相比,HCT 在全球范围内稳步增加,区域之间的差距正在缩小,同种异体的增加幅度更大。虽然相关 HCT 正在上升,主要是由于半相合 HCT 的增加,但无关的是平台和脐带血下降。HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋 (SEA/WPR) 为 53.6,非洲/东地中海 (AFR/EMR) 为 27.8 . 有趣的是,半相合 TR 在 SEA/WPR 中为 32%,在拉丁美洲为 26%,但在欧洲和 EMR 中仅为 14%,在所有同种异体 HCT 中为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲最高 (7.7),其次是北美 (6.0)、SEA/WPR (1.9)、拉丁美洲 (1.6) 和 AFR/EMR (0.4)。与自体活动相比,HCT 在全球范围内稳步增加,区域之间的差距正在缩小,同种异体的增加幅度更大。虽然相关 HCT 正在上升,主要是由于半相合 HCT 的增加,但无关的是平台和脐带血下降。HCT/1000 万人口)因地区而异,北美为 560.8,欧洲为 438.5,拉丁美洲为 76.7,东南亚/西太平洋 (SEA/WPR) 为 53.6,非洲/东地中海 (AFR/EMR) 为 27.8 . 有趣的是,半相合 TR 在 SEA/WPR 中为 32%,在拉丁美洲为 26%,但在欧洲和 EMR 中仅为 14%,在所有同种异体 HCT 中为 4.9%。HCT 团队密度(团队/1000 万人口)在欧洲最高 (7.7),其次是北美 (6.0)、SEA/WPR (1.9)、拉丁美洲 (1.6) 和 AFR/EMR (0.4)。与自体活动相比,HCT 在全球范围内稳步增加,区域之间的差距正在缩小,同种异体的增加幅度更大。虽然相关 HCT 正在上升,主要是由于半相合 HCT 的增加,但无关的是平台和脐带血下降。
更新日期:2021-08-12
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