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Fixation of Transparent Bone Pins with Photocuring Biocomposites
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-13 , DOI: 10.1021/acsbiomaterials.1c00473 Gautama Wicaksono 1 , Felicia Toni 1 , Leonard Wei Feng Tok 1 , Jeanette Jun Ting Thng 1 , Ivan Šolić 1 , Manisha Singh 1 , Ivan Djordjevic 1 , Francesco Baino 2 , Terry W J Steele 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-13 , DOI: 10.1021/acsbiomaterials.1c00473 Gautama Wicaksono 1 , Felicia Toni 1 , Leonard Wei Feng Tok 1 , Jeanette Jun Ting Thng 1 , Ivan Šolić 1 , Manisha Singh 1 , Ivan Djordjevic 1 , Francesco Baino 2 , Terry W J Steele 1
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Bone fractures are in need of rapid fixation methods, but the current strategies are limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques are sought to avoid surgical revisions, while maintaining or improving the fixation speed. Herein, a method of bone fixation is proposed with transparent biopolymers anchored in place via light-activated biocomposites based on expanding CaproGlu bioadhesives. The transparent biopolymers serve as a UV light guide for the activation of CaproGlu biocomposites, which results in evolution of molecular nitrogen (from diazirine photolysis), simultaneously expanding the covalently cross-linked matrix. Osseointegration additives of hydroxyapatite or Bioglass 45S5 yield a biocomposite matrix with increased stiffness and pullout strength. The structure–property relationships of UV joules dose, pin diameter, and biocomposite additives are assessed with respect to the apparent viscosity, shear modulus, spatiotemporal pin curing, and lap-shear adhesion. Finally, a model system is proposed based on ex vivo investigation with bone tissue for the exploration and optimization of UV-active transparent biopolymer fixation.
中文翻译：
用光固化生物复合材料固定透明骨针
骨折需要快速的固定方法，但目前的策略仅限于金属销钉和螺钉，这需要在移除时进行二次手术。寻求新技术以避免手术修正，同时保持或提高固定速度。在此，提出了一种骨固定方法，通过基于膨胀 CaproGlu 生物粘合剂的光活化生物复合材料将透明生物聚合物固定到位。透明的生物聚合物用作激活 CaproGlu 生物复合材料的 UV 光导，这导致分子氮的演变（来自二氮嗪光解），同时扩大共价交联的基质。羟基磷灰石或生物玻璃 45S5 的骨整合添加剂产生具有更高刚度和拉拔强度的生物复合基质。根据表观粘度、剪切模量、时空针固化和搭接剪切粘附评估紫外线焦耳剂量、针直径和生物复合添加剂的结构-性能关系。最后，提出了一个基于模型的系统骨组织离体研究，探索和优化紫外线活性透明生物聚合物固定。
更新日期：2021-09-13
中文翻译：
用光固化生物复合材料固定透明骨针
骨折需要快速的固定方法，但目前的策略仅限于金属销钉和螺钉，这需要在移除时进行二次手术。寻求新技术以避免手术修正，同时保持或提高固定速度。在此，提出了一种骨固定方法，通过基于膨胀 CaproGlu 生物粘合剂的光活化生物复合材料将透明生物聚合物固定到位。透明的生物聚合物用作激活 CaproGlu 生物复合材料的 UV 光导，这导致分子氮的演变（来自二氮嗪光解），同时扩大共价交联的基质。羟基磷灰石或生物玻璃 45S5 的骨整合添加剂产生具有更高刚度和拉拔强度的生物复合基质。根据表观粘度、剪切模量、时空针固化和搭接剪切粘附评估紫外线焦耳剂量、针直径和生物复合添加剂的结构-性能关系。最后，提出了一个基于模型的系统骨组织离体研究，探索和优化紫外线活性透明生物聚合物固定。
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