The Fruit of Gold: Biomimicry in the Syntheses of Lankacidins,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The Fruit of Gold: Biomimicry in the Syntheses of Lankacidins
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-08-12 , DOI: 10.1021/acs.accounts.1c00340
Kuan Zheng ₁ , Ran Hong _{1,

2}

Affiliation

Natural products are constructed by organisms in impressive ways through various highly selective enzyme-catalyzed chemical reactions. Over the past century, there has been considerable interest in understanding and emulating the underlying biosynthetic logic for the target molecule. The successful implementation of a biomimetic strategy usually has some uniquely valuable benefits over other abiotic routes in total synthesis by (1) corroborating the chemical feasibility of a given biogenetic hypothesis and further unraveling some insightful implications for future biosynthetic studies and (2) providing remarkably more concise access to not only the original synthetic target but also diversified biogenetically related congeners, which may result in either the structural reassignment of previously disclosed natural products or the anticipation of undiscovered natural products. However, for the devised essential biomimetic transformation, fine-tuning the optimization of the substrates and the reaction conditions can sometimes be painstakingly challenging. Turning to nature for inspiration can provide additional impetus for methodological innovations.

中文翻译：

黄金之果：兰卡西汀合成中的仿生学

天然产物是由生物体通过各种高度选择性的酶催化化学反应以令人印象深刻的方式构建的。在过去的一个世纪里，人们对理解和模拟目标分子的潜在生物合成逻辑产生了相当大的兴趣。仿生策略的成功实施通常比全合成中的其他非生物途径具有一些独特的有价值的好处，因为 (1) 证实了给定生物遗传学假设的化学可行性，并进一步揭示了对未来生物合成研究的一些有见地的影响，以及 (2) 提供了更多不仅可以简明地访问原始合成目标，还可以访问多样化的生物遗传相关同源物，这可能导致先前公开的天然产物的结构重新分配或未发现的天然产物的预期。然而，对于设计的基本仿生转化，微调底物和反应条件的优化有时会非常具有挑战性。向自然寻求灵感可以为方法创新提供额外的动力。

更新日期：2021-09-07

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11