An anti-cancer effect of Sambou bamboo saltTM in melanoma skin cancer both in vivo and in vitro models,Journal of Food Biochemistry

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An anti-cancer effect of Sambou bamboo saltTM in melanoma skin cancer both in vivo and in vitro models
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-08-13 , DOI: 10.1111/jfbc.13903
Hee-Yun Kim ₁ , Dongkyun Han ₂ , Jungeun Kim ₂ , Min-Sun Yoo ₃ , Jin-Soo Lee ₄ , Hyunyong Kim ₃ , Hyung-Min Kim _{3,

4} , Hyun-Ja Jeong _{1,

2}

Affiliation

Bamboo salt has anti-allergic, anti-inflammatory, anti-oxidant, diabetics, anti-aging, and immune-enhancing effects, which are closely related to anti-cancer effect. The aim of this study was to investigate the anti-cancer effects of Sambou bamboo salt^TM (SBS) in melanoma skin cancer in vivo and in vitro models. SBS-administered mice effectively reduced tumor growth and increased survival rate compared with B16F10 cell-inoculated mice without tissue damage, hepatotoxicity, and nephrotoxicity. SBS enhanced levels of immune-enhancing mediators, such as interferon-γ, interleukin (IL)-2, IL-6, IL-12, tumor necrosis factor-α, and IgE in serum and melanoma tissues. Furthermore, SBS enhanced activities of caspases and levels of Bax and p53, whereas decreased levels of Bcl-2. This reduction was a consequence of apoptosis signaling pathway. In conclusion, these results suggest that SBS is a potential substance for cancer therapy. SBS has the potential to be developed either as Korean traditional medicine or as a health functional food for cancer therapy.

中文翻译：

Sambou竹盐TM在体内和体外模型中对黑色素瘤皮肤癌的抗癌作用

竹盐具有抗过敏、抗炎、抗氧化、抗糖尿病、抗衰老、增强免疫等作用，与抗癌作用密切相关。本研究的目的是研究三宝竹盐^{TM 的}抗癌作用。(SBS) 在体内和体外模型中的黑色素瘤皮肤癌。与没有组织损伤、肝毒性和肾毒性的 B16F10 细胞接种小鼠相比，SBS 给药的小鼠有效地减少了肿瘤生长并提高了存活率。SBS 提高了免疫增强介质的水平，例如干扰素-γ、白细胞介素 (IL)-2、IL-6、IL-12、肿瘤坏死因子-α 和血清和黑色素瘤组织中的 IgE。此外，SBS 增强了半胱天冬酶的活性以及 Bax 和 p53 的水平，而降低了 Bcl-2 的水平。这种减少是细胞凋亡信号通路的结果。总之，这些结果表明 SBS 是一种潜在的癌症治疗物质。SBS 有可能被开发为韩国传统药物或癌症治疗的健康功能食品。

更新日期：2021-09-06

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