Surgical incision infection of multidrug-resistant microorganisms (e.g., methicillin-resistant Staphylococcus aureus, MRSA) is a severe cause of poor wound healing, which is prevalent in healthcare facilities and constitutes a huge infectious disease burden in the world. The purpose of this study is to investigate the medical application and possible mechanisms of the cold atmospheric plasma jet on infected wounds. In this article, the New Zealand rabbit in vivo wound infected with MRSA is used as the wound healing animal model. The helium atmospheric-pressure dielectric-barrier-discharge (AP-DBD) plasma jet is employed to treat the wounds infected with MRSA. The wound healing, histological, and cytokine analyses are conducted to evaluate the efficacy of the helium AP-DBD plasma jet on the MRSA-infected wound healing process. The experimental results show that the helium AP-DBD plasma jet treatment on the wounds infected with MRSA can regulate the secretion of the cytokines, limit the inflammatory response and cell excessive proliferation, accelerate the process of re-epithelialization, and consequently, promote the wound healing process and the inactivation of the bacteria.

中文翻译：

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冷气氛等离子体射流促进耐甲氧西林金黄色葡萄球菌感染兔体内伤口愈合


多重耐药微生物（例如耐甲氧西林金黄色葡萄球菌，MRSA）的手术切口感染是伤口愈合不良的严重原因，在医疗机构中普遍存在，并构成了世界上巨大的传染病负担。本研究的目的是研究冷大气等离子体射流在感染伤口上的医学应用和可能的机制。本文采用感染MRSA的新西兰兔体内伤口作为伤口愈合动物模型。氦气大气压介质阻挡放电（AP-DBD）等离子射流用于治疗感染 MRSA 的伤口。进行伤口愈合、组织学和细胞因子分析，以评估氦 AP-DBD 等离子体射流对 MRSA 感染的伤口愈合过程的功效。实验结果表明，氦AP-DBD等离子体射流治疗MRSA感染创面可以调节细胞因子的分泌，限制炎症反应和细胞过度增殖，加速上皮化过程，从而促进创面愈合。愈合过程和细菌失活。