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Monolithic polymeric porous superhydrophobic material with pneumatic plastron stabilization for functionally durable drag reduction in blood-contacting biomedical applications
NPG Asia Materials ( IF 9.7 ) Pub Date : 2021-08-13 , DOI: 10.1038/s41427-021-00325-9
Jennifer Marlena 1 , Justin Kok Soon Tan 1 , Zenggan Lin 1 , Hwa Liang Leo 1 , Sangho Kim 1 , David Xinzheyang Li 2 , Boxin Zhao 3 , Choon Hwai Yap 4
Affiliation  

Superhydrophobic (SHP) surfaces can provide substantial reductions in flow drag forces and reduce blood damage in cardiovascular medical devices. However, strategies for functional durability are necessary, as many SHP surfaces have low durability under abrasion or strong fluid jetting or eventually lose their air plastron and slip-flow capabilities due to plastron gas dissolution, high fluid pressure, or fouling. Here, we present a functional material that extends the functional durability of superhydrophobic slip flow. Facile modification of a porous superhydrophobic polytetrafluoroethylene (PTFE, Teflon) foam produced suitable surface structures to enable fluid slip flow and resist protein fouling. Its monolithic nature offered abrasion durability, while its porosity allowed pressurized air to be supplied to resist fluid impalement and to replenish the air plastron lost to the fluid through dissolution. Active pore pressure control could resist high fluid pressures and turbulent flow conditions across a wide range of applied pressures. The pneumatically stabilized material yielded large drag reductions (up to 50%) even with protein fouling, as demonstrated from high-speed water jetting and closed loop pressure drop tests. Coupled with its high hemocompatibility and impaired protein adsorption, this easily fabricated material can be viable for incorporation into blood-contacting medical devices.



中文翻译:

具有气动腹甲稳定功能的整体聚合物多孔超疏水材料,可在血液接触生物医学应用中实现功能持久的减阻

超疏水 (SHP) 表面可以显着降低流动阻力并减少心血管医疗设备中的血液损伤。然而,功能耐久性策略是必要的,因为许多 SHP 表面在磨损或强流体喷射下的耐久性低,或者最终会由于腹板气体溶解、高流体压力或污垢而失去其空气腹板和滑流能力。在这里,我们提出了一种功能材料,可扩展超疏水滑流的功能耐久性。对多孔超疏水性聚四氟乙烯(PTFE、Teflon)泡沫的简单改性产生了合适的表面结构,使流体能够滑流并防止蛋白质污染。它的整体性质提供了耐磨性,而它的孔隙率允许提供加压空气以抵抗流体穿刺并补充由于溶解而损失到流体中的空气腹甲。主动孔隙压力控制可以在广泛的应用压力范围内抵抗高流体压力和湍流条件。正如高速水喷射和闭环压降测试所证明的那样,气动稳定的材料即使在蛋白质污染的情况下也能产生很大的阻力降低(高达 50%)。再加上其高血液相容性和受损的蛋白质吸附,这种易于制造的材料可用于与血液接触的医疗设备中。正如高速水喷射和闭环压降测试所证明的那样,气动稳定的材料即使在蛋白质污染的情况下也能产生很大的阻力降低(高达 50%)。再加上其高血液相容性和受损的蛋白质吸附,这种易于制造的材料可用于与血液接触的医疗设备中。正如高速水喷射和闭环压降测试所证明的那样,气动稳定的材料即使在蛋白质污染的情况下也能产生很大的阻力降低(高达 50%)。再加上其高血液相容性和受损的蛋白质吸附,这种易于制造的材料可用于与血液接触的医疗设备中。

更新日期:2021-08-13
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