ABSTRACT

Purpose

Investigate the effect of botulinum toxin type-A (BoNT-A) on spasticity and motor performance in children with Cerebral Palsy (CP) related to Congenital Zika Syndrome (CZS).

Methods

Prospective longitudinal observational study of 34 children with CP referred for BoNT-A treatment. Outcomes were evaluated with a muscle tone assessment scale (Modified Ashworth Scale – MAS) and the Patients’ Global Impression of Improvement (PGI-I) scale.

Results:

Mean age was 32.06 ± 3.07 months and 85% were classified as Gross Motor Function Classification System (GMFCS) V. Primitive reflexes were present in 56% of the sample. The majority of the parents (97.9%) reported improvement in range of motion or reduction in spasticity after treatment with botulinum toxin. No side effects were recorded. When compared to the baseline, median reduction in the MAS was 0.5 (IQR = 0).

Conclusions

The findings of this study suggest that BoNT-A may effectively promote functional improvements and reduce muscle tone, improving the child’s and family’s quality of life.

中文翻译：

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A 型肉毒杆菌毒素在先天性寨卡综合征相关脑瘫痉挛中的作用：一项观察性研究

摘要

目的

研究 A 型肉毒杆菌毒素 (BoNT-A) 对与先天性寨卡综合征 (CZS) 相关的脑性麻痹 (CP) 儿童的痉挛和运动表现的影响。

方法

对 34 名接受 BoNT-A 治疗的 CP 儿童进行的前瞻性纵向观察研究。使用肌肉张力评估量表（改良的 Ashworth 量表 - MAS）和患者的整体改善印象（PGI-I）量表评估结果。

结果：

平均年龄为 32.06 ± 3.07 个月，85% 被归类为粗大运动功能分类系统 (GMFCS) V。56% 的样本存在原始反射。大多数父母 (97.9%) 报告说，在接受肉毒杆菌毒素治疗后，活动范围有所改善或痉挛减少。没有记录到副作用。与基线相比，MAS 的中位数减少为 0.5 (IQR = 0)。

结论

这项研究的结果表明，BoNT-A 可以有效促进功能改善和降低肌肉张力，从而改善儿童和家庭的生活质量。