Polygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether PRSs associate more with general or with specific psychopathology in school-aged children. Additionally, we tested whether psychiatric PRSs can be combined into a multi-PRS score for improved performance.

中文翻译：

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不同精神特征的组合多基因风险评分可预测儿童时期的一般和特定精神病理学


多基因风险评分（PRS）可操作特定精神障碍的遗传倾向，并有望作为精神病理学的早期预测因子，但在 PRS 应用于临床之前，必须增强解释力并建立精神病学领域的特异性。为了实现早期发现，研究儿童时期的这些心理测量特性至关重要。我们研究了 PRS 是否与学龄儿童的一般或特定精神病理学相关更多。此外，我们还测试了是否可以将精神科 PRS 合并到多 PRS 评分中以提高表现。