Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay,European Journal of Immunology

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Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay
European Journal of Immunology ( IF 4.5 ) Pub Date : 2021-08-13 , DOI: 10.1002/eji.202149296
William Mouton _{1,

2,

3} , Christelle Compagnon _{1,

3} , Kahina Saker ₁ , Soizic Daniel ₄ , Sophia Djebali ₂ , Xavier Lacoux ₄ , Bruno Pozzetto _{5,

6} , Guy Oriol _{1,

3} , Daphné Laubreton ₂ , Margaux Prieux ₂ , Jean-Baptiste Fassier _{7,

8} , Nicolas Guibert _{7,

8} , Amélie Massardier-Pilonchéry _{7,

8} , Dulce Alfaiate _{7,

8} , Franck Berthier ₄ , Thierry Walzer ₂ , Jacqueline Marvel ₂ , Karen Brengel-Pesce _{1,

3} , Sophie Trouiller-Assant _{1,

2}

Affiliation

Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.

中文翻译：

使用标准化全血干扰素伽马释放测定法特异性检测 COVID-19 患者的记忆 T 细胞

抗原特异性 T 细胞对于 SARS-CoV-2 的保护性免疫至关重要。我们建立了半自动全血干扰素伽马释放测定（WB IGRA）来监测 SARS-CoV-2 肽池刺激后的 T 细胞反应。我们报告说，WB IGRA 是对评估 SARS-CoV-2 免疫力的血清学检测的补充。

更新日期：2021-08-13

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