The Continuous Automated Model EvaluatiOn (CAMEO) platform complements the biennial CASP experiment by conducting fully automated blind evaluations of three-dimensional protein prediction servers based on the weekly prerelease of sequences of those structures, which are going to be published in the upcoming release of the Protein Data Bank. While in CASP14, significant success was observed in predicting the structures of individual protein chains with high accuracy, significant challenges remain in correctly predicting the structures of complexes. By implementing fully automated evaluation of predictions for protein–protein complexes, as well as for proteins in complex with ligands, peptides, nucleic acids, or proteins containing noncanonical amino acid residues, CAMEO will assist new developments in those challenging areas of active research.

中文翻译：

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连续自动模型评估 (CAMEO) — 对结构预测方法全自动评估的未来展望

连续自动模型评估 (CAMEO) 平台通过对 3D 蛋白质预测服务器进行全自动盲评估来补充两年一次的 CASP 实验，该评估基于这些结构的序列的每周预发布，这些结构的序列将在即将发布的蛋白质数据库。虽然在 CASP14 中，在以高精度预测单个蛋白质链的结构方面取得了重大成功，但在正确预测复合物的结构方面仍然存在重大挑战。通过对蛋白质-蛋白质复合物以及与配体、肽、核酸或含有非规范氨基酸残基的蛋白质复合的蛋白质的预测进行全自动评估，CAMEO 将有助于那些具有挑战性的活跃研究领域的新发展。