Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (p = 0.021 and p = 0.016, respectively) and at 1 year versus baseline (both p < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.

中文翻译：

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青少年和青年肉瘤患者服用蒽环类药物后骨骼肌质量的短期变化

鉴定蒽环类药物引起的肌肉损失对于维持青少年和年轻成人 (AYA) 癌症患者的健康至关重要。我们使用常规胸部计算机断层扫描 (CT) 扫描来研究 16 名 AYA 肉瘤患者在接受蒽环类药物治疗后第 4 节胸椎 (T4) 骨骼肌的变化。在三个时间点（化疗前、化疗后和 1 年）检查 CT 图像。化疗后（分别为p  = 0.021 和p  = 0.016）和 1 年与基线相比（均p  < 0.05），总骨骼肌指数和密度发生显着变化。这项研究支持使用 T4 作为 AYA 骨骼肌损失的早期指标。