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Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants
Science ( IF 56.9 ) Pub Date : 2021-08-12 , DOI: 10.1126/science.abj4176 Amarendra Pegu 1 , Sarah E O'Connell 1 , Stephen D Schmidt 1 , Sijy O'Dell 1 , Chloe A Talana 1 , Lilin Lai 2 , Jim Albert 3 , Evan Anderson 2 , Hamilton Bennett 4 , Kizzmekia S Corbett 1 , Britta Flach 1 , Lisa Jackson 5 , Brett Leav 4 , Julie E Ledgerwood 1 , Catherine J Luke 6 , Mat Makowski 3 , Martha C Nason 1 , Paul C Roberts 6 , Mario Roederer 1 , Paulina A Rebolledo 7 , Christina A Rostad 2 , Nadine G Rouphael 7 , Wei Shi 1 , Lingshu Wang 1 , Alicia T Widge 1 , Eun Sung Yang 1 , , John H Beigel 6 , Barney S Graham 1 , John R Mascola 1 , Mehul S Suthar 2 , Adrian B McDermott 1 , Nicole A Doria-Rose 1 , Jae Arega , John H Beigel , Wendy Buchanan , Mohammed Elsafy , Binh Hoang , Rebecca Lampley , Aparna Kolhekar , Hyung Koo , Catherine Luke , Mamodikoe Makhene , Seema Nayak , Rhonda Pikaart-Tautges , Paul C Roberts , Janie Russell , Elisa Sindall , Jim Albert , Pratap Kunwar , Mat Makowski , Evan J Anderson , Amer Bechnak , Mary Bower , Andres F Camacho-Gonzalez , Matthew Collins , Ana Drobeniuc , Venkata Viswanadh Edara , Srilatha Edupuganti , Katharine Floyd , Theda Gibson , Cassie M Grimsley Ackerley , Brandi Johnson , Satoshi Kamidani , Carol Kao , Colleen Kelley , Lilin Lai , Hollie Macenczak , Michele Paine McCullough , Etza Peters , Varun K Phadke , Paulina A Rebolledo , Christina A Rostad , Nadine Rouphael , Erin Scherer , Amy Sherman , Kathy Stephens , Mehul S Suthar , Mehgan Teherani , Jessica Traenkner , Juton Winston , Inci Yildirim , Lee Barr , Joyce Benoit , Barbara Carste , Joe Choe , Maya Dunstan , Roxanne Erolin , Jana Ffitch , Colin Fields , Lisa A Jackson , Erika Kiniry , Susan Lasicka , Stella Lee , Matthew Nguyen , Stephanie Pimienta , Janice Suyehira , Michael Witte , Hamilton Bennett , Nedim Emil Altaras , Andrea Carfi , Marjorie Hurley , Brett Leav , Rolando Pajon , Wellington Sun , Tal Zaks , Rhea N Coler , Sasha E Larsen , Kathleen M Neuzil , Lisa C Lindesmith , David R Martinez , Jennifer Munt , Michael Mallory , Caitlin Edwards , Ralph S Baric , Nina M Berkowitz , Eli A Boritz , Kevin Carlton , Kizzmekia S Corbett , Pamela Costner , Adrian Creanga , Nicole A Doria-Rose , Daniel C Douek , Britta Flach , Martin Gaudinski , Ingelise Gordon , Barney S Graham , LaSonji Holman , Julie E Ledgerwood , Kwanyee Leung , Bob C Lin , Mark K Louder , John R Mascola , Adrian B McDermott , Kaitlyn M Morabito , Laura Novik , Sarah O'Connell , Sijy O'Dell , Marcelino Padilla , Amarendra Pegu , Stephen D Schmidt , Wei Shi , Phillip A Swanson , Chloe A Talana , Lingshu Wang , Alicia T Widge , Eun Sung Yang , Yi Zhang , James D Chappell , Mark R Denison , Tia Hughes , Xiaotao Lu , Andrea J Pruijssers , Laura J Stevens , Christine M Posavad , Michael Gale , Vineet Menachery , Pei-Yong Shi
Science ( IF 56.9 ) Pub Date : 2021-08-12 , DOI: 10.1126/science.abj4176 Amarendra Pegu 1 , Sarah E O'Connell 1 , Stephen D Schmidt 1 , Sijy O'Dell 1 , Chloe A Talana 1 , Lilin Lai 2 , Jim Albert 3 , Evan Anderson 2 , Hamilton Bennett 4 , Kizzmekia S Corbett 1 , Britta Flach 1 , Lisa Jackson 5 , Brett Leav 4 , Julie E Ledgerwood 1 , Catherine J Luke 6 , Mat Makowski 3 , Martha C Nason 1 , Paul C Roberts 6 , Mario Roederer 1 , Paulina A Rebolledo 7 , Christina A Rostad 2 , Nadine G Rouphael 7 , Wei Shi 1 , Lingshu Wang 1 , Alicia T Widge 1 , Eun Sung Yang 1 , , John H Beigel 6 , Barney S Graham 1 , John R Mascola 1 , Mehul S Suthar 2 , Adrian B McDermott 1 , Nicole A Doria-Rose 1 , Jae Arega , John H Beigel , Wendy Buchanan , Mohammed Elsafy , Binh Hoang , Rebecca Lampley , Aparna Kolhekar , Hyung Koo , Catherine Luke , Mamodikoe Makhene , Seema Nayak , Rhonda Pikaart-Tautges , Paul C Roberts , Janie Russell , Elisa Sindall , Jim Albert , Pratap Kunwar , Mat Makowski , Evan J Anderson , Amer Bechnak , Mary Bower , Andres F Camacho-Gonzalez , Matthew Collins , Ana Drobeniuc , Venkata Viswanadh Edara , Srilatha Edupuganti , Katharine Floyd , Theda Gibson , Cassie M Grimsley Ackerley , Brandi Johnson , Satoshi Kamidani , Carol Kao , Colleen Kelley , Lilin Lai , Hollie Macenczak , Michele Paine McCullough , Etza Peters , Varun K Phadke , Paulina A Rebolledo , Christina A Rostad , Nadine Rouphael , Erin Scherer , Amy Sherman , Kathy Stephens , Mehul S Suthar , Mehgan Teherani , Jessica Traenkner , Juton Winston , Inci Yildirim , Lee Barr , Joyce Benoit , Barbara Carste , Joe Choe , Maya Dunstan , Roxanne Erolin , Jana Ffitch , Colin Fields , Lisa A Jackson , Erika Kiniry , Susan Lasicka , Stella Lee , Matthew Nguyen , Stephanie Pimienta , Janice Suyehira , Michael Witte , Hamilton Bennett , Nedim Emil Altaras , Andrea Carfi , Marjorie Hurley , Brett Leav , Rolando Pajon , Wellington Sun , Tal Zaks , Rhea N Coler , Sasha E Larsen , Kathleen M Neuzil , Lisa C Lindesmith , David R Martinez , Jennifer Munt , Michael Mallory , Caitlin Edwards , Ralph S Baric , Nina M Berkowitz , Eli A Boritz , Kevin Carlton , Kizzmekia S Corbett , Pamela Costner , Adrian Creanga , Nicole A Doria-Rose , Daniel C Douek , Britta Flach , Martin Gaudinski , Ingelise Gordon , Barney S Graham , LaSonji Holman , Julie E Ledgerwood , Kwanyee Leung , Bob C Lin , Mark K Louder , John R Mascola , Adrian B McDermott , Kaitlyn M Morabito , Laura Novik , Sarah O'Connell , Sijy O'Dell , Marcelino Padilla , Amarendra Pegu , Stephen D Schmidt , Wei Shi , Phillip A Swanson , Chloe A Talana , Lingshu Wang , Alicia T Widge , Eun Sung Yang , Yi Zhang , James D Chappell , Mark R Denison , Tia Hughes , Xiaotao Lu , Andrea J Pruijssers , Laura J Stevens , Christine M Posavad , Michael Gale , Vineet Menachery , Pei-Yong Shi
Affiliation
SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the impact of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and ACE2-competing antibodies elicited by the vaccine mRNA-1273 over seven months. Cross-reactive neutralizing responses were rare after a single dose. At the peak of response to the second vaccine dose, all individuals had responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6-months after the primary series of the mRNA-1273 vaccine. Across all assays, B.1.351 had the lowest antibody recognition. These data complement ongoing studies to inform the potential need for additional boost vaccinations.
中文翻译：
mRNA-1273 疫苗诱导的针对 SARS-CoV-2 变体的抗体的耐久性
SARS-CoV-2 突变可能会减弱疫苗诱导的保护性免疫反应，特别是当抗体滴度随着时间的推移而减弱时。在这里，我们评估了 SARS-CoV-2 变体 B.1.1.7 (Alpha)、B.1.351 (Beta)、P.1 (Gamma)、B.1.429 (Epsilon)、B.1.526 (Iota)、 B.1.617.2（Delta）对疫苗 mRNA-1273 在七个月内引发的结合、中和和 ACE2 竞争抗体的影响。单剂量后交叉反应中和反应很少见。在对第二剂疫苗的反应高峰时，所有个体对所有变体都有反应。在初次接种 mRNA-1273 疫苗后的 6 个月内，针对变异体的结合抗体和功能抗体在大多数受试者中持续存在，尽管水平较低。在所有测定中，B.1.351 的抗体识别率最低。这些数据补充了正在进行的研究，以告知是否需要额外加强疫苗接种。
更新日期：2021-09-10
中文翻译：
mRNA-1273 疫苗诱导的针对 SARS-CoV-2 变体的抗体的耐久性
SARS-CoV-2 突变可能会减弱疫苗诱导的保护性免疫反应，特别是当抗体滴度随着时间的推移而减弱时。在这里，我们评估了 SARS-CoV-2 变体 B.1.1.7 (Alpha)、B.1.351 (Beta)、P.1 (Gamma)、B.1.429 (Epsilon)、B.1.526 (Iota)、 B.1.617.2（Delta）对疫苗 mRNA-1273 在七个月内引发的结合、中和和 ACE2 竞争抗体的影响。单剂量后交叉反应中和反应很少见。在对第二剂疫苗的反应高峰时，所有个体对所有变体都有反应。在初次接种 mRNA-1273 疫苗后的 6 个月内，针对变异体的结合抗体和功能抗体在大多数受试者中持续存在，尽管水平较低。在所有测定中，B.1.351 的抗体识别率最低。这些数据补充了正在进行的研究，以告知是否需要额外加强疫苗接种。
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