Hepatocellular carcinoma (HCC) is one of the most common subtypes of malignant liver tumors, characterized by high morbidity and mortality. Due to its poor diagnosis strategy and inefficient clinical intervention, HCC has brought terrible life experiences for patients worldwide. Finding novel curative agents for HCC is urgently needed. In the current study, we hypothesized that lncRNA PANTR1 participates in HCC initiation or progression. Our study found that lncRNA PANTR1 was upregulated in HCC tumor tissues and abundantly expressed in HCC cell lines. PANTR1 knockdown inhibited cell growth and migration, promoted cell apoptosis in vitro, and suppressed tumor cell growth in vivo. Moreover, our results suggest that downregulated PANTR1 inhibited the Warburg effect in HCC cells. Underlying mechanisms of PANTR1 in HCC progression were investigated. PANTR1 acted as a competent sponge for miR-587 and downregulated miR-587 expression in HCC cells. Further, MiR-587 directly targets BCL2A1. lncRNA PANTR1 promotes HCC progression via mediating the miR-587-BCL2A1 axis. Our study identified a novel lncRNA PANTR1/miR-587/BCL2A1 axis in HCC progression. We might provide a new target for HCC basic research and clinical management.

中文翻译：

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lncRNA PANTR1通过抑制miR-587上调BCL2A1表达促进肝细胞癌的肿瘤发生和Warburg效应

肝细胞癌（HCC）是最常见的恶性肝肿瘤亚型之一，具有高发病率和高死亡率的特点。由于其诊断策略不佳和临床干预效率低下，HCC给全世界的患者带来了可怕的生活经历。迫切需要寻找新的治疗 HCC 的药物。在目前的研究中，我们假设 lncRNA PANTR1 参与了 HCC 的起始或进展。我们的研究发现，lncRNA PANTR1 在 HCC 肿瘤组织中上调，并在 HCC 细胞系中大量表达。PANTR1敲低抑制细胞生长和迁移，在体外促进细胞凋亡，在体内抑制肿瘤细胞生长. 此外，我们的结果表明下调的 PANTR1 抑制了 HCC 细胞中的 Warburg 效应。研究了 PANTR1 在 HCC 进展中的潜在机制。PANTR1 充当 miR-587 的感受态海绵并下调 HCC 细胞中的 miR-587 表达。此外，MiR-587 直接针对 BCL2A1。lncRNA PANTR1 通过介导 miR-587-BCL2A1 轴促进 HCC 进展。我们的研究在 HCC 进展中发现了一个新的 lncRNA PANTR1/miR-587/BCL2A1 轴。我们可能为HCC基础研究和临床管理提供一个新的靶点。