A green, flexible, and effective strategy was proposed to quantify four target compounds (muscone, ethyl palmitate, ethyl oleate, and ethylparaben) from musk by binary eluent based vortex-assisted matrix solid-phase dispersion (MSPD) extraction coupled with GC/MS. Single-factor tests and orthogonal design were employed to optimize the MSPD parameters. In addition, the binary eluent system, methanol, and ethyl acetate 3 : 7 (v/v) were used to extract the target analytes. Finally, C₁₈ was applied as the easily available dispersant and the sample powder was ground for 2 min. Thereafter, the mixture was rapidly extracted with the binary eluents under whirling for 3 min. Eventually, the analysis of the samples was completed within 12 min by GC/MS. All correlation coefficients (r) of four targets were more than 0.9991. The recoveries of all target compounds ranged from 92.8% to 101% while their RSDs were less than 6.94%. There was no significant matrix interference for the analysis. Thus, the combination of vortex-assisted MSPD with GC/MS was considered as a novel, rapid, and environmentally friendly quantitative approach for musk samples.

中文翻译：

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基于二元洗脱液的涡流辅助基质固相分散体，用于通过气相色谱-质谱法从麝香中提取和测定多组分

提出了一种绿色、灵活且有效的策略，通过基于二元洗脱液的涡流辅助基质固相分散 (MSPD) 萃取结合 GC/MS 对麝香中的四种目标化合物（麝香酮、棕榈酸乙酯、油酸乙酯和对羟基苯甲酸乙酯）进行定量. 采用单因素试验和正交设计来优化 MSPD 参数。此外，使用二元淋洗液系统、甲醇和乙酸乙酯 3:7 (v/v) 提取目标分析物。最后，使用C ₁₈作为易于获得的分散剂，并将样品粉末研磨 2 分钟。此后，混合物在旋转下用二元洗脱液快速萃取 3 分钟。最终，样品的分析在 12 分钟内通过 GC/MS 完成。所有相关系数 ( r) 的四个目标均超过 0.9991。所有目标化合物的回收率范围为 92.8% 至 101%，而其 RSD 均小于 6.94%。分析没有显着的基质干扰。因此，涡流辅助 MSPD 与 GC/MS 的结合被认为是一种新颖、快速且环保的麝香样品定量方法。