The effective components of Coptis chinensis were extracted by ultrasound-assisted technology, and the contents of palmatine and berberine were used as indexes by using Coptis chinensis as raw material and eutectic solvent as extractant. In addition, the effects of hydrogen bond donor type, molar ratio of hydrogen bond donor to acceptor, material-liquid ratio, water content of eutectic solvent system, sonication time, power, and ultrasonic temperature on the extraction rate of palmatine and berberine were studied. The optimum extraction technology of palmatine and berberine from Coptis chinensis was determined by single-factor experiment and response surface optimization test. As a result, it showed that the eutectic solvent system was constructed with choline chloride as hydrogen bond acceptor and phenol as hydrogen bond donor, with a molar ratio of 1 : 3. In addition, water content of the eutectic solvent system was 30%, ratio of material to liquid was 30 g/mL, ultrasonic time was 30 min, ultrasonic power was 200 W, and ultrasonic temperature was 60°C. At this time, the contents of palmatine and berberine in Coptis chinensis were 16.7145 mg/g and 57.4013 mg/g, respectively, which were predicted to be the same as the value, and the extraction effect was better than that of traditional extraction solvent method.

中文翻译：

---

低共熔溶剂超声辅助提取有效提取黄连中的巴马汀和小檗碱

以黄连为原料，低共熔溶剂为提取剂，采用超声辅助技术提取黄连有效成分，以巴马汀和小檗碱的含量为指标。此外,考察了氢键供体类型、氢键供体与受体摩尔比、料液比、共晶溶剂体系含水量、超声时间、功率、超声温度等因素对巴马汀和小檗碱提取率的影响。 。通过单因素试验和响应面优化试验，确定了黄连巴马汀和小檗碱的最佳提取工艺。结果表明，以氯化胆碱为氢键受体，苯酚为氢键供体，摩尔比为1:3构建了共晶溶剂体系。另外，共晶溶剂体系的含水量为30%，料液比为30 g/mL，超声时间为30 min，超声功率为200 W，超声温度为60℃。此时黄连中巴马汀和小檗碱的含量分别为16.7145 mg/g和57.4013 mg/g，与预测值一致，提取效果优于传统提取溶剂法。 。