Background

Persistent systemic inflammation leads to multidistrectual body dysfunctions. Attenuation of inflammation may improve patients’ functional and life prognoses. We hypothesized that essential amino acids (EAAs) given to elderly patients in rehabilitation after acute diseases may be associated with a reduced inflammatory state. Therefore, this retrospective study investigated whether the supplementation of EAAs – modulators of immune competence – was associated with a reduced inflammation rate in elderly patients.

Methods

The medical records of 282 patients admitted to the rehabilitation (rehab) institute after acute index events (surgery or medical diseases) (age: 81.18 ± 8.58 years; females: 67.9%) were analyzed.

Results

46 patients (16.3% of the entire population) had received EAA supplements (S), whereas the remaining 236 patients had not (N-S). Systemic inflammation (I) (serum C-reactive protein (CRP) > 0.5 mg/dL) was present in 67.4% of the I-S group and 57.2% of the I-N-S group. During rehab, the I-S group (but not the I-N-S group) showed a reduction in CRP levels (p = 0.03) and an increase in circulating lymphocytes (p = 0.035), immune cells of the adaptive immune system. C-reactive protein levels remained virtually unchanged in non-inflamed patients who received supplements but increased in non-inflamed patients who did not receive supplements (p = 0.05). Stratified for developed infections, CRP levels reduced in S patients (p = 0.008) but did not in N-S patients.

Conclusion

EAA supplementation was associated with reduced inflammation in both inflamed and infected patients. In addition, EAA supplementation was associated with increased circulating lymphocytes in inflamed patients.

中文翻译：

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补充必需氨基酸与急性炎症后老年患者血清 C 反应蛋白水平降低和循环淋巴细胞改善有关

背景

持续的全身炎症导致多分布的身体功能障碍。炎症的减轻可以改善患者的功能和生命预后。我们假设在急性疾病后康复中给予老年患者必需氨基酸 (EAA) 可能与炎症状态降低有关。因此，这项回顾性研究调查了补充 EAA（免疫能力调节剂）是否与老年患者的炎症率降低有关。

方法

分析了在急性指数事件（手术或内科疾病）后入住康复（康复）机构的 282 名患者的病历（年龄：81.18 ± 8.58 岁；女性：67.9%）。

结果

46 名患者（占总人口的 16.3%）接受了 EAA 补充剂（S），而其余 236 名患者没有（NS）。67.4% 的 IS 组和 57.2% 的 INS 组存在全身性炎症 (I)（血清 C 反应蛋白 (CRP) > 0.5 mg/dL）。在康复期间，IS 组（但不是 INS 组）显示 CRP 水平降低（p = 0.03）和循环淋巴细胞增加（p = 0.035），适应性免疫系统的免疫细胞。接受补充剂的非炎症患者的 C 反应蛋白水平几乎保持不变，但未接受补充剂的非炎症患者的 C 反应蛋白水平升高（p = 0.05）。针对已发生的感染分层，S 患者的 CRP 水平降低（p = 0.008) 但在 NS 患者中没有。

结论

EAA 补充剂与炎症和感染患者的炎症减少有关。此外，补充 EAA 与发炎患者的循环淋巴细胞增加有关。