当前位置: X-MOL 学术Genet. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial
Genetics in Medicine ( IF 6.6 ) Pub Date : 2021-08-12 , DOI: 10.1038/s41436-021-01292-w
Amelia K Smit 1, 2 , Martin Allen 3 , Brooke Beswick 1 , Phyllis Butow 4 , Hugh Dawkins 5, 6 , Suzanne J Dobbinson 7 , Kate L Dunlop 1 , David Espinoza 8 , Georgina Fenton 1 , Peter A Kanetsky 9 , Louise Keogh 10 , Michael G Kimlin 11 , Judy Kirk 12 , Matthew H Law 13, 14 , Serigne Lo 2 , Cynthia Low 15 , Graham J Mann 2, 16 , Gillian Reyes-Marcelino 1 , Rachael L Morton 2, 8 , Ainsley J Newson 17 , Jacqueline Savard 18 , Lyndal Trevena 19 , Sarah Wordsworth 20 , Anne E Cust 1, 2
Affiliation  

Purpose

We evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes.

Methods

In this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18–69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline.

Results

At 12 months, 948 (92%) participants completed dosimetry and 973 (95%) the questionnaire. For the primary outcome, there was no effect of the genomic risk intervention on objectively measured UV exposure at 12 months, irrespective of traditional risk factors. For secondary outcomes at 12 months, the intervention reduced sunburns (risk ratio: 0.72, 95% confidence interval: 0.54–0.96), and increased skin examinations among women. Melanoma-related worry was reduced. There was no overall impact on general psychological distress.

Conclusion

Personalized genomic risk information did not influence sun exposure patterns but did improve some skin cancer prevention and early detection behaviors, suggesting it may be useful for precision prevention. There was no evidence of psychological harm.



中文翻译:

个人基因组风险信息对黑色素瘤预防行为和心理结果的影响:一项随机对照试验

目的

我们评估了个人黑色素瘤基因组风险信息对太阳相关行为和心理结果的影响。

方法

在这个平行组中,开放的随机对照试验通过 Medicare 数据库招募了 1,025 名没有黑色素瘤且年龄在 18-69 岁的欧洲血统的澳大利亚人(3% 的同意)。参与者被随机分配到干预组(n  = 513;用于基因检测的唾液样本、基于 40 种多基因风险评分的个性化黑色素瘤风险手册、基于电话的遗传咨询、教育手册)或对照组(n  = 512;教育手册) . 在基线、干预后 1 个月和基线后 12 个月进行腕戴式紫外线 (UV) 辐射剂量计(佩戴 10 天)和问卷调查。

结果

在 12 个月时,948 名 (92%) 参与者完成了剂量测定,973 名 (95%) 完成了问卷调查。对于主要结果,无论传统风险因素如何,基因组风险干预对客观测量的 12 个月紫外线暴露没有影响。对于 12 个月的次要结果,干预减少了晒伤(风险比:0.72,95% 置信区间:0.54-0.96),并增加了女性的皮肤检查。黑色素瘤相关的担忧减少了。对一般心理困扰没有总体影响。

结论

个性化的基因组风险信息不会影响阳光照射模式,但确实改善了一些皮肤癌的预防和早期检测行为,这表明它可能对精确预防有用。没有证据表明有心理伤害。

更新日期:2021-08-13
down
wechat
bug