RNA-binding motif protein 39 (RBM39), as a key factor in tumor-targeted mRNA and protein expression, not only plays a vital role in tumorigenesis, but also has broad development prospects in clinical treatment and drug research. Moreover, since RBM39 was identified as a target of sulfonamides, it has played a key role in the emerging field of molecule drug development. Hence, it is of great significance to study the interaction between RBM39 and tumors and the clinical application of drug-targeted therapy. In this paper, we describe the possible multi-level regulation of RBM39, including gene transcription, protein translation, and alternative splicing. Importantly, the molecular function of RBM39 as an important splicing factor in most common tumors is systematically outlined. Furthermore, we briefly introduce RBM39’s tumor-targeted drug research and its clinical application, hoping to give reference significance for the molecular mechanism of RBM39 in tumors, and provide reliable ideas for in-depth research for future therapeutic strategies.

RNA结合基序蛋白39（RBM39）作为肿瘤靶向mRNA和蛋白表达的关键因素，不仅在肿瘤发生中起着至关重要的作用，而且在临床治疗和药物研究中具有广阔的发展前景。此外，由于 RBM39 被确定为磺胺类药物的靶点，它在分子药物开发的新兴领域发挥了关键作用。因此，研究RBM39与肿瘤的相互作用以及药物靶向治疗的临床应用具有重要意义。在本文中，我们描述了 RBM39 可能的多级调控，包括基因转录、蛋白质翻译和选择性剪接。重要的是，系统概述了 RBM39 作为最常见肿瘤中重要剪接因子的分子功能。此外，