Versatile Synthesis of Diaminoxylosides via Iodosulfonamidation of Xylal Derivatives,European Journal of Organic Chemistry

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Versatile Synthesis of Diaminoxylosides via Iodosulfonamidation of Xylal Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-08-13 , DOI: 10.1002/ejoc.202100792
Sven Ole Jaeschke ₁ , Thisbe K. Lindhorst ₂

Affiliation

The power of iodosulfonamidation of glycals was used for the synthesis of 2,4-diaminoxylosides, which are of interest as conformational switches. The synthetic pathway proceeds from an l-arabino configuration over a glycal with two stereocenters in a threo relation to the d-xylo configuration of the product with compelling selectivity.