Creutzfeldt–Jakob disease (CJD) is a transmissible spongiform encephalopathy characterized by rapid onset and high mortality. Despite considerable progress in the treatment and diagnosis of CJD, patient prognosis remains poor. Many studies have found that the immune response is associated with the pathophysiology of CJD. However, few studies have reported coexpression correlations between genes associated with CJD and the immune response. This study was undertaken to construct a network of coexpressed immune- and CJD-related genes that may reveal new biomarkers and therapeutic targets for CJD.

中文翻译：

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构建免疫/克雅氏病相关基因共表达网络以预测生物标志物

克雅氏病 (CJD) 是一种传染性海绵状脑病，特点是发病迅速，死亡率高。尽管在 CJD 的治疗和诊断方面取得了长足的进步，但患者的预后仍然很差。许多研究发现，免疫反应与 CJD 的病理生理学有关。然而，很少有研究报道与 CJD 相关的基因与免疫反应之间的共表达相关性。本研究旨在构建一个共表达的免疫和 CJD 相关基因网络，这些基因可能揭示 CJD 的新生物标志物和治疗靶点。