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Bacterial approaches to sensing and responding to respiration and respiration metabolites
Molecular Microbiology ( IF 3.6 ) Pub Date : 2021-08-13 , DOI: 10.1111/mmi.14795
Erin E Price 1 , Franklin Román-Rodríguez 1 , Jeffrey M Boyd 1
Affiliation  

Bacterial respiration of diverse substrates is a primary contributor to the diversity of life. Respiration also drives alterations in the geosphere and tethers ecological nodes together. It provides organisms with a means to dissipate reductants and generate potential energy in the form of an electrochemical gradient. Mechanisms have evolved to sense flux through respiratory pathways and sense the altered concentrations of respiration substrates or byproducts. These genetic regulatory systems promote efficient utilization of respiration substrates, as well as fine-tune metabolism to promote cellular fitness and negate the accumulation of toxic byproducts. Many bacteria can respire one or more chemicals, and these regulatory systems promote the prioritization of high-energy metabolites. Herein, we focus on regulatory paradigms and discuss systems that sense the concentrations of respiration substrates and flux through respiratory pathways. This is a broad field of study, and therefore we focus on key fundamental and recent developments and highlight specific systems that capture the diversity of sensing mechanisms.

中文翻译:

感知和响应呼吸和呼吸代谢物的细菌方法

不同底物的细菌呼吸是生命多样性的主要贡献者。呼吸作用还驱动地球圈的变化,并将生态节点连接在一起。它为有机体提供了一种消散还原剂并以电化学梯度的形式产生势能的方法。机制已经发展到感知通过呼吸途径的通量并感知呼吸底物或副产物浓度的变化。这些遗传调控系统促进呼吸底物的有效利用,以及微调新陈代谢以促进细胞适应性并消除有毒副产物的积累。许多细菌可以呼吸一种或多种化学物质,这些调节系统促进了高能代谢物的优先排序。在此处,我们专注于监管范式并讨论感知呼吸底物浓度和通过呼吸途径的通量的系统。这是一个广泛的研究领域,因此我们专注于关键的基础和最新发展,并强调捕捉传感机制多样性的特定系统。
更新日期:2021-08-13
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