With the ongoing emergence of SARS-CoV-2 variants and potential to evade vaccine-induced neutralisation, understanding the magnitude and breadth of vaccine-induced T-cell immunity will be critical for the ongoing optimisation of vaccine approaches. Strategies that provide a rapid and easily translatable means of assessing virus-specific T-cell responses provide an opportunity to monitor the impact of vaccine rollouts in the community. In this study, we assessed whether our recently developed SARS-CoV-2 whole-blood assay could be used effectively to analyse T-cell responses following vaccination.

中文翻译：

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单剂阿斯利康 ChAdOx1-S COVID-19 疫苗后快速全血检测检测 SARS-CoV-2 特异性记忆 T 细胞免疫

随着 SARS-CoV-2 变体的不断出现和逃避疫苗诱导的中和的潜力，了解疫苗诱导的 T 细胞免疫的幅度和广度对于持续优化疫苗方法至关重要。提供快速且易于翻译的方法来评估病毒特异性 T 细胞反应的策略为监测疫苗在社区中推出的影响提供了机会。在这项研究中，我们评估了我们最近开发的 SARS-CoV-2 全血检测是否可以有效地用于分析疫苗接种后的 T 细胞反应。