Naturally occurring peptides found in the human skin can serve particular biological activities and play roles as signaling molecules of various physiological processes such as homeostasis, growth, defense or immunity. Their great biological activity resulted in a growing interest in the pharmaceutical industry. Researchers consider peptides either promising compounds with potential application for human diagnosis, therapy or cosmetics. Peptides are becoming interesting cosmetic ingredients with the functions to reduce premature skin aging, improve the barrier function of skin, moisturize the skin, protect it from UV damage, and anti-inflammatory properties that alleviate acne and irritation. Till now, peptides of different origins were investigated in formulation developed to enhance collagen or elastin production, increase fibroblast proliferation, improve wound healing or skin condition. Most of them are obtained by chemical synthesis or by partial digestion of animal proteins. Short and easily synthesized peptides with alternative amino acid sequence, and combinations have created a new field of molecules inspired by nature and implemented in the cosmetic industry. Nowadays, peptides are cheaper and easier to produce in large quantities. The efficient process development methods allow obtaining nearly unlimited sequences, which makes them functionally preferred. Generally, cosmetic peptides are categorized as carrier peptides, neurotransmitter- affecting peptides, enzyme inhibitor peptides and signal peptides. The use of signal peptides in cosmetics increased over a few years. These molecules trigger a signaling cascade and stimulate fibroblast collagen production, the proliferation of elastin, fibronectin, laminin, etc. Thus, a literature search on a topical application of the most common signal peptides; and their current status in the cosmetic industry was carried out.

中文翻译：

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Signal Peptides - 化妆品中的有前途的成分。

在人体皮肤中发现的天然肽可以发挥特定的生物活性，并作为各种生理过程的信号分子，如体内平衡、生长、防御或免疫。它们巨大的生物活性引起了人们对制药工业的日益浓厚的兴趣。研究人员认为肽是一种有前景的化合物，可用于人类诊断、治疗或化妆品。肽正在成为有趣的化妆品成分，具有减少皮肤过早老化、改善皮肤屏障功能、滋润皮肤、保护皮肤免受紫外线伤害以及减轻痤疮和刺激的抗炎特性。到目前为止，不同来源的肽在配方中被研究以增强胶原蛋白或弹性蛋白的产生，增加成纤维细胞增殖，改善伤口愈合或皮肤状况。它们大多是通过化学合成或动物蛋白质的部分消化而获得的。具有替代氨基酸序列的短且易于合成的肽及其组合创造了一个受自然启发并在化妆品行业实施的分子新领域。如今，肽更便宜，更容易大批量生产。高效的工艺开发方法允许获得几乎无限的序列，这使得它们在功能上更受欢迎。一般来说，化妆品肽分为载体肽、影响神经递质的肽、酶抑制剂肽和信号肽。信号肽在化妆品中的使用在几年内有所增加。这些分子触发信号级联并刺激成纤维细胞胶原蛋白的产生、弹性蛋白、纤连蛋白、层粘连蛋白等的增殖。因此，对最常见信号肽的局部应用进行文献检索；并对其在化妆品行业的现状进行了调查。