当前位置：
X-MOL 学术
›
Neural Regener. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index.
Neural Regeneration Research ( IF 5.9 ) Pub Date : 2022-03-01 , DOI: 10.4103/1673-5374.320996 Heng Zhao 1 , Fang Wang 2 , Guang-Hua Luo 2 , Hao Lei 2 , Fei Peng 2 , Qiu-Ping Ren 2 , Wei Chen 2 , Yan-Fang Wu 2 , Li-Chun Yin 2 , Jin-Cai Liu 2 , Shi-Nong Pan 3
Neural Regeneration Research ( IF 5.9 ) Pub Date : 2022-03-01 , DOI: 10.4103/1673-5374.320996 Heng Zhao 1 , Fang Wang 2 , Guang-Hua Luo 2 , Hao Lei 2 , Fei Peng 2 , Qiu-Ping Ren 2 , Wei Chen 2 , Yan-Fang Wu 2 , Li-Chun Yin 2 , Jin-Cai Liu 2 , Shi-Nong Pan 3
Affiliation
Patients with type 2 diabetes mellitus (T2DM) often have cognitive impairment and structural brain abnormalities. The magnetic resonance imaging (MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function, and can therefore also be used to reflect whole-brain structural changes related to T2DM. A total of 136 participants (64 men and 72 women, aged 55-86 years) were recruited for our study between January 2014 and December 2016. All participants underwent MRI and Mini-Mental State Examination assessment (including 42 healthy control, 38 T2DM without cognitive impairment, 26 with cognitive impairment but without T2DM, and 30 T2DM with cognitive impairment participants). The total and sub-category brain atrophy and lesion index scores in patients with T2DM with cognitive impairment were higher than those in healthy controls. Differences in the brain atrophy and lesion index of gray matter lesions and subcortical dilated perivascular spaces were found between non-T2DM patients with cognitive impairment and patients with T2DM and cognitive impairment. After adjusting for age, the brain atrophy and lesion index retained its capacity to identify patients with T2DM with cognitive impairment. These findings suggest that the brain atrophy and lesion index, based on T1-weighted and T2-weighted imaging, is of clinical value for identifying patients with T2DM and cognitive impairment. Gray matter lesions and subcortical dilated perivascular spaces may be potential diagnostic markers of T2DM that is complicated by cognitive impairment. This study was approved by the Medical Ethics Committee of University of South China (approval No. USC20131109003) on November 9, 2013, and was retrospectively registered with the Chinese Clinical Trial Registry (registration No. ChiCTR1900024150) on June 27, 2019.
更新日期：2021-08-13
京公网安备 11010802027423号