Discrimination of stereoisomers by one-dimensional 13C NMR: All 16 stereoisomers of 4-hydroxy-α-tocopherol resolved,Magnetic Resonance in Chemistry

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Discrimination of stereoisomers by one-dimensional 13C NMR: All 16 stereoisomers of 4-hydroxy-α-tocopherol resolved
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2021-08-10 , DOI: 10.1002/mrc.5202
Peter P Lankhorst ₁ , Alexander L L Duchateau ₁ , Thomas Netscher ₂

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All 16 resolved! A vitamin E-derived compound containing four chiral centers is the first example where all stereoisomers, that is, eight diastereomeric pairs of enantiomers, could be discriminated in a single NMR run. Measurement at 176 MHz in the presence of Pirkle's alcohol as a chiral solvating agent is a relatively robust, simple, easy-to-set-up, and fast method.

中文翻译：

通过一维 13C NMR 区分立体异构体：4-羟基-α-生育酚的所有 16 种立体异构体均已解析

16个都解决了！含有四个手性中心的维生素 E 衍生化合物是第一个例子，其中所有立体异构体，即八个对映异构体的非对映异构体对，可以在一次 NMR 运行中区分。在 Pirkle 醇作为手性溶剂化剂存在的情况下，在 176 MHz 下进行测量是一种相对稳健、简单、易于设置且快速的方法。

更新日期：2021-10-04

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