A number of recent investigations have focused on the neurobiology of obsessive–compulsive personality disorder (OCPD). However, there have been few reviews of this literature with no detailed model proposed. We therefore undertook a systematic review of these investigations, aiming to map the available evidence and investigate whether it is possible to formulate a detailed model of the neurobiology of OCPD.

OCPD can be considered from both categorical and dimensional perspectives. An electronic search was therefore conducted using terms that would address not only OCPD as a category, but also related constructs, such as perfectionism, that would capture research on neuropsychology, neuroimaging, neurochemistry, and neurogenetics.

A total of 1059 articles were retrieved, with 87 ultimately selected for abstract screening, resulting in a final selection of 49 articles focusing on neurobiological investigations relevant to OCPD. Impaired executive function and cognitive inflexibility are common neuropsychological traits in this condition, and suggest that obsessive–compulsive disorder (OCD) and OCPD may lie on a continuum. However, neuroimaging studies in OCPD indicate the involvement of specific neurocircuitry, including the precuneus and amygdala, and so suggest that OCD and OCPD may have important differences. Although OCPD has a heritable component, we found no well-powered genetic studies of OCPD.

Although knowledge in this area has advanced, there are insufficient data on which to base a comprehensive model of the neurobiology of OCPD. Given the clinical importance of OCPD, further work to understand the mechanisms that underpin this condition is warranted.

最近的一些调查集中在强迫性人格障碍 (OCPD) 的神经生物学上。然而，很少有没有提出详细模型的文献综述。因此，我们对这些调查进行了系统审查，旨在绘制可用证据并调查是否有可能制定 OCPD 神经生物学的详细模型。

OCPD 可以从类别和维度的角度考虑。因此，使用不仅将 OCPD 作为一个类别，而且还包括相关结构（例如完美主义）的术语进行电子搜索，这些术语将捕获神经心理学、神经影像学、神经化学和神经遗传学的研究。

共检索到 1059 篇文章，最终选择 87 篇进行摘要筛选，最终选择了 49 篇专注于与 OCPD 相关的神经生物学研究的文章。执行功能受损和认知不灵活是这种情况下常见的神经心理学特征，表明强迫症 (OCD) 和 OCPD 可能存在于一个连续统一体中。然而，OCPD 的神经影像学研究表明特定神经回路的参与，包括楔前叶和杏仁核，因此表明 OCD 和 OCPD 可能存在重要差异。尽管 OCPD 具有可遗传的成分，但我们没有发现针对 OCPD 的强有力的遗传研究。

尽管这方面的知识有所进步，但没有足够的数据来建立 OCPD 神经生物学的综合模型。鉴于 OCPD 的临床重要性，有必要进一步研究支持这种情况的机制。