Combating bacteria while promoting tissue regeneration is an aim of highest priority for employing biomaterials in orthopedics that often embroiled with pre-operative contamination. Through simulating a surgical site infection environment and an infected implant site, we showcase the ability of a functionally modified hydroxyapatite, Ag,Si-HA that permits preferential adhesion of human bone marrow derived mesenchymal stem cells (BMSCs) over co-cultured bacterial pathogen, Pseudomonas aeruginosa, by displaying immediate suppression and killing of the bacteria present with minimum cytotoxicity for 28 d. And, at the same time, Ag,Si-HA stimulates BMSCs towards osteogenic differentiation despite being within the contaminated milieu. These findings provide well-defined requirements for incorporating antibacterial properties to biomaterials in managing pre-operative contamination. In addition, it highlights the dual positive attributes of Ag,Si-HA as an effective antibacterial biomaterial and at the same time, promotes bone tissue regeneration.

在促进组织再生的同时抗击细菌是在骨科中使用生物材料的最高优先目标，骨科通常卷入术前污染。通过模拟手术部位感染环境和受感染的植入部位，我们展示了功能修饰的羟基磷灰石 Ag,Si-HA 的能力，它允许人骨髓间充质干细胞 (BMSCs) 优先粘附于共培养的细菌病原体，铜绿假单胞菌，通过在 28 天内显示立即抑制和杀死具有最小细胞毒性的细菌。同时，Ag,Si-HA 刺激 BMSCs 向成骨分化，尽管在受污染的环境中。这些发现为将抗菌特性结合到生物材料中以管理术前污染提供了明确的要求。此外，它突出了Ag、Si-HA作为有效抗菌生物材料的双重积极属性，同时促进骨组织再生。