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Broadly neutralizing antibody–derived CAR T cells reduce viral reservoir in individuals infected with HIV-1
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2021 , DOI: 10.1172/jci150211 Bingfeng Liu 1, 2 , Wanying Zhang 1 , Baijin Xia 1 , Shuliang Jing 1 , Yingying Du 1 , Fan Zou 1, 3 , Rong Li 1 , Lijuan Lu 1 , Shaozhen Chen 2 , Yonghong Li 2 , Qifei Hu 3 , Yingtong Lin 1 , Yiwen Zhang 1 , Zhangping He 1 , Xu Zhang 1 , Xiejie Chen 2 , Tao Peng 4 , Xiaoping Tang 2 , Weiping Cai 2 , Ting Pan 1 , Linghua Li 2 , Hui Zhang 1
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2021 , DOI: 10.1172/jci150211 Bingfeng Liu 1, 2 , Wanying Zhang 1 , Baijin Xia 1 , Shuliang Jing 1 , Yingying Du 1 , Fan Zou 1, 3 , Rong Li 1 , Lijuan Lu 1 , Shaozhen Chen 2 , Yonghong Li 2 , Qifei Hu 3 , Yingtong Lin 1 , Yiwen Zhang 1 , Zhangping He 1 , Xu Zhang 1 , Xiejie Chen 2 , Tao Peng 4 , Xiaoping Tang 2 , Weiping Cai 2 , Ting Pan 1 , Linghua Li 2 , Hui Zhang 1
Affiliation
BACKGROUND. Chimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We have developed a broadly neutralizing antibody–derived (bNAb-derived) CAR T cell therapy that can exert specific cytotoxic activity against HIV-1–infected cells.
中文翻译：
广泛中和抗体衍生的 CAR T 细胞减少感染 HIV-1 的个体的病毒库
背景。嵌合抗原受体 (CAR) T 细胞已成为治疗恶性肿瘤的一种方法。这种策略也被提议用于治疗 HIV-1 感染。我们开发了一种广泛中和抗体衍生（bNAb 衍生）的 CAR T 细胞疗法，它可以对 HIV-1 感染的细胞发挥特定的细胞毒活性。
更新日期：2021-10-02
中文翻译：
广泛中和抗体衍生的 CAR T 细胞减少感染 HIV-1 的个体的病毒库
背景。嵌合抗原受体 (CAR) T 细胞已成为治疗恶性肿瘤的一种方法。这种策略也被提议用于治疗 HIV-1 感染。我们开发了一种广泛中和抗体衍生（bNAb 衍生）的 CAR T 细胞疗法，它可以对 HIV-1 感染的细胞发挥特定的细胞毒活性。
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