In people with advanced respiratory disease, we examined (i) the impact of COVID-19–related physical and social isolation on physical activity and (ii) relationships between time spent in isolation and disability in activities of daily living. Cross-sectional analysis was conducted in adults with advanced non-small cell lung cancer, chronic obstructive lung disease or interstitial lung disease. Measures included change in physical activity since physically and socially isolating (Likert scale) and disability (Barthel Index and Lawton–Brody IADL scale) or difficulty (World Health Organisation Disability Assessment Schedule-2.0) in daily activities. Multiple logistic regression was used to examine factors associated with disability in daily activities. 194/201 participants were isolating for a median [IQR] 5 [3–8]-month period, often leading to lower levels of physical activity at home (n = 94, 47%), and outside home (n = 129, 65%). 104 (52%) and 142 (71%) were not fully independent in basic and instrumental activities of daily living, respectively. 96% reported some degree of difficulty in undertaking daily activities. Prolonged physical and social isolation related to increased disability in basic (r = −0.28, p < 0.001) and instrumental (r = −0.24, p < 0.001) activities of daily living, and greater difficulty in daily activities (r = 0.22, p = 0.002). Each month spent in physical or social isolation was independently related to disability in basic activities of daily living (odds ratio [OR], 1.17 [95% CI: 1.03–1.33], p = 0.013). These findings suggest disability in daily activities is associated with prolonged physical or social isolation, which may present as difficulty in people who are fully independent. Post-isolation recovery and rehabilitation needs should be considered for all people deemed extremely clinically vulnerable.

在患有晚期呼吸系统疾病的人中，我们检查了 (i) 与 COVID-19 相关的身体和社会隔离对身体活动的影响，以及 (ii) 隔离时间与日常生活活动残疾之间的关系。在患有晚期非小细胞肺癌、慢性阻塞性肺病或间质性肺病的成人中进行了横断面分析。措施包括自身体和社会隔离（李克特量表）和残疾（巴塞尔指数和劳顿-布罗迪 IADL 量表）或日常活动困难（世界卫生组织残疾评估表 2.0）以来身体活动的变化。多元逻辑回归用于检查与日常活动中的残疾相关的因素。194/201 名参与者被隔离的时间中位数 [IQR] 5 [3–8] 个月，n = 94, 47%)，以及外出 ( n = 129, 65%)。104 人 (52%) 和 142 人 (71%) 分别不能完全独立进行基本的日常生活活动和工具性活动。96% 的人表示在进行日常活动时有一定程度的困难。长期的身体和社会隔离与日常生活中基本 (r = −0.28, p < 0.001) 和工具性 (r = −0.24, p < 0.001) 活动的残疾增加以及日常活动难度增加 (r = 0.22, p = 0.002）。每个月在身体或社会孤立中度过的时间与日常生活基本活动的残疾独立相关（比值比 [OR]，1.17 [95% CI：1.03–1.33]，p= 0.013）。这些研究结果表明，日常活动中的残疾与长期的身体或社会孤立有关，这可能对完全独立的人来说是困难的。应考虑所有被认为在临床上极度脆弱的人的隔离后恢复和康复需求。