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White Matter Hyperintensities of Bilateral Lenticular Putamen in Patients with Proliferative Diabetic Retinopathy: A Voxel‐based Morphometric Study
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-08-12 , DOI: 10.2147/dmso.s321270 Ang Xiao 1 , Qian-Min Ge 1 , Hui-Feng Zhong 2 , Li-Juan Zhang 1 , Hui-Ye Shu 1 , Rong-Bin Liang 1 , Yi Shao 1 , Qiong Zhou 1
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-08-12 , DOI: 10.2147/dmso.s321270 Ang Xiao 1 , Qian-Min Ge 1 , Hui-Feng Zhong 2 , Li-Juan Zhang 1 , Hui-Ye Shu 1 , Rong-Bin Liang 1 , Yi Shao 1 , Qiong Zhou 1
Affiliation
Objective: To explore the changes in gray matter volume (GMV) and white matter volume (WMV) in proliferative diabetic retinopathy (PDR) patients using voxel-based morphometry (VBM).
Participants and Methods: In total, 15 patients (10 males, 5 females) with PDR were enrolled to the patient group and 15 healthy controls (10 males, 5 females) to the control group, matched for age, sex, handedness, and education status. All individuals underwent voxel-based morphometry scans. GMV and WMV were compared between the two groups.
Results: GMV in bilateral superior temporal gyrus, sixth area of left cerebellum, left middle temporal gyrus, left orbital inferior frontal gyrus and left middle cingulum gyrus and WMV in left thalamus and left precuneus were significantly lower in patients than controls (P< 0.01). Conversely, WMV was significantly higher in bilateral lenticular putamen of patients than controls (P< 0.01).
Conclusion: Abnormal GMV and WMV in many specific areas of the cerebrum provide new insights for exploration of the occurrence and development of DR and its pathophysiology.
Keywords: voxel-based morphometric, white matter, gray matter, proliferative diabetic retinopathy
中文翻译：
增殖性糖尿病视网膜病变患者双侧豆状核壳白质高信号：基于体素的形态测量研究
目的：利用基于体素的形态计量学（VBM）探讨增殖性糖尿病视网膜病变（PDR）患者灰质体积（GMV）和白质体积（WMV）的变化。
参与者和方法：共有15名PDR患者（10名男性，5名女性）被纳入患者组，15名健康对照者（10名男性，5名女性）被纳入对照组，年龄、性别、惯用手和受教育程度相匹配地位。所有个体都接受了基于体素的形态测量扫描。比较两组的GMV和WMV。
结果：患者双侧颞上回、左侧小脑第六区、左侧颞中回、左侧眶下回、左侧中扣带回GMV、左侧丘脑、左侧楔前叶WMV均显着低于对照组（P <0.01）。相反，患者双侧透镜状壳核的WMV显着高于对照组（P < 0.01）。
结论：大脑许多特定区域的异常GMV和WMV为探索DR的发生发展及其病理生理学提供了新的思路。
关键词：基于体素的形态测量，白质，灰质，增殖性糖尿病视网膜病变
更新日期：2021-08-12
Participants and Methods: In total, 15 patients (10 males, 5 females) with PDR were enrolled to the patient group and 15 healthy controls (10 males, 5 females) to the control group, matched for age, sex, handedness, and education status. All individuals underwent voxel-based morphometry scans. GMV and WMV were compared between the two groups.
Results: GMV in bilateral superior temporal gyrus, sixth area of left cerebellum, left middle temporal gyrus, left orbital inferior frontal gyrus and left middle cingulum gyrus and WMV in left thalamus and left precuneus were significantly lower in patients than controls (P< 0.01). Conversely, WMV was significantly higher in bilateral lenticular putamen of patients than controls (P< 0.01).
Conclusion: Abnormal GMV and WMV in many specific areas of the cerebrum provide new insights for exploration of the occurrence and development of DR and its pathophysiology.
Keywords: voxel-based morphometric, white matter, gray matter, proliferative diabetic retinopathy
中文翻译：
增殖性糖尿病视网膜病变患者双侧豆状核壳白质高信号：基于体素的形态测量研究
目的：利用基于体素的形态计量学（VBM）探讨增殖性糖尿病视网膜病变（PDR）患者灰质体积（GMV）和白质体积（WMV）的变化。
参与者和方法：共有15名PDR患者（10名男性，5名女性）被纳入患者组，15名健康对照者（10名男性，5名女性）被纳入对照组，年龄、性别、惯用手和受教育程度相匹配地位。所有个体都接受了基于体素的形态测量扫描。比较两组的GMV和WMV。
结果：患者双侧颞上回、左侧小脑第六区、左侧颞中回、左侧眶下回、左侧中扣带回GMV、左侧丘脑、左侧楔前叶WMV均显着低于对照组（P <0.01）。相反，患者双侧透镜状壳核的WMV显着高于对照组（P < 0.01）。
结论：大脑许多特定区域的异常GMV和WMV为探索DR的发生发展及其病理生理学提供了新的思路。
关键词：基于体素的形态测量，白质，灰质，增殖性糖尿病视网膜病变
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