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Tau-targeting antibody therapies: too late, wrong epitope or wrong target?
Nature Medicine ( IF 58.7 ) Pub Date : 2021-08-12 , DOI: 10.1038/s41591-021-01465-9 Edwin Jabbari 1, 2 , Karen E Duff 3, 4
Nature Medicine ( IF 58.7 ) Pub Date : 2021-08-12 , DOI: 10.1038/s41591-021-01465-9 Edwin Jabbari 1, 2 , Karen E Duff 3, 4
Affiliation
Two phase 2 studies of N-terminal tau–targeting antibody therapy fail to show clinical efficacy in progressive supranuclear palsy, despite evidence of target engagement.
中文翻译:
Tau 靶向抗体疗法:为时已晚、错误的表位或错误的靶点?
尽管有靶向作用的证据,但两项 N 端 tau 靶向抗体疗法的 2 期研究未能显示对进行性核上性麻痹的临床疗效。
更新日期:2021-08-12
中文翻译:
Tau 靶向抗体疗法:为时已晚、错误的表位或错误的靶点?
尽管有靶向作用的证据,但两项 N 端 tau 靶向抗体疗法的 2 期研究未能显示对进行性核上性麻痹的临床疗效。