Chronic low-grade inflammation in heart failure with preserved ejection fraction,Aging Cell

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Chronic low-grade inflammation in heart failure with preserved ejection fraction
Aging Cell ( IF 8.0 ) Pub Date : 2021-08-12 , DOI: 10.1111/acel.13453
Thassio Mesquita ₁ , Yen-Nien Lin ₁ , Ahmed Ibrahim ₁

Affiliation

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form of HF with a dramatic increase in risk with age. Low-grade inflammation, as occurs with aging (termed “inflammaging”), is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated HFpEF disease severity and better outcomes. From this perspective, inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression. However, the causal link between the inflammasome-immune signaling axis on the age-dependent progression of HFpEF remains conjectural. In this review, we summarize the current understanding of the role of inflammatory pathways in age-dependent cardiac function decline. We will also evaluate recent advances and evidence regarding the inflammatory pathway in the pathophysiology of HFpEF, with special attention to inflammasome signaling.

中文翻译：

射血分数保留的心力衰竭的慢性低度炎症

射血分数保留的心力衰竭 (HFpEF) 是目前 HF 的主要形式，其风险随着年龄的增长而急剧增加。随着衰老而发生的低度炎症（称为“炎症”）是 HFpEF 病理学的一个共同特征。促炎途径的抑制与减轻 HFpEF 疾病严重程度和更好的预后相关。从这个角度来看，炎症体信号传导在介导慢性炎症和心血管疾病进展中发挥着核心作用。然而，炎症小体-免疫信号轴与 HFpEF 年龄依赖性进展之间的因果关系仍然是推测的。在这篇综述中，我们总结了目前对炎症途径在年龄依赖性心功能下降中的作用的理解。我们还将评估有关 HFpEF 病理生理学炎症通路的最新进展和证据，特别关注炎症体信号传导。

更新日期：2021-09-15

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