As one of the problems and diseases for women before 40 years, premature ovarian failure (POF) could be characterized by amenorrhea, low estrogen levels, infertility, high gonadotropin levels, and lack of mature follicles. Causes of the disease involve some genetic disorders, autoimmunity diseases, and environmental factors. Various approaches have been employed to treat POF, however with limited success. Today, stem cells are used to treat POF, since they have the potential to self-repair and regenerate, and are effective in treating ovarian failure and infertility. As mesenchymal stem cell (MSC) could simultaneously activate several mechanisms, many researchers consider MSC transplantation to be the best and most effective approach in cell therapy. A good source for mesenchymal stem cells is human umbilical cord (HUCMSC). Animal models with cyclophosphamide are required for stem cell treatment and performance of HUCMSC transplantation. Stem cell therapy could indicate the levels of ovarian markers and follicle-stimulating hormone receptor. It also increases ovarian weight, plasma E2 levels, and the amount of standard follicles. Herein, the causes of POF, effective treatment strategies, and the effect of HUCMSC transplantation for the treatment of premature ovarian failure are reviewed. Many studies have been conducted in this field, and the results have shown that stem cell treatment is an effective approach to treat infertility.

中文翻译：

---

人脐带间充质干细胞移植治疗卵巢早衰

卵巢早衰（POF）是40岁之前女性面临的问题和疾病之一，其特点是闭经、雌激素水平低、不孕、促性腺激素水平高、缺乏成熟卵泡。该病的病因涉及一些遗传性疾病、自身免疫性疾病和环境因素。人们已经采用了多种方法来治疗 POF，但效果有限。如今，干细胞被用来治疗 POF，因为它们具有自我修复和再生的潜力，并且可以有效治疗卵巢功能衰竭和不孕症。由于间充质干细胞（MSC）可以同时激活多种机制，许多研究人员认为间充质干细胞移植是细胞治疗中最好、最有效的方法。间充质干细胞的良好来源是人脐带（HUCMSC）。干细胞治疗和 HUCMSC 移植需要使用环磷酰胺动物模型。干细胞治疗可以指示卵巢标志物和卵泡刺激激素受体的水平。它还会增加卵巢重量、血浆 E2 水平和标准卵泡的数量。本文就POF的病因、有效治疗策略以及HUCMSC移植治疗卵巢早衰的效果进行综述。在这一领域已经进行了许多研究，结果表明干细胞治疗是治疗不孕症的有效方法。