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Shape Memory Polymer Foams with Tunable Degradation Profiles
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-11 , DOI: 10.1021/acsabm.1c00516 Anand Utpal Vakil 1 , Natalie Marie Petryk 1 , Ellen Shepherd 1 , Henry T Beaman 1 , Priya S Ganesh 1 , Katheryn S Dong 1 , Mary Beth B Monroe 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-08-11 , DOI: 10.1021/acsabm.1c00516 Anand Utpal Vakil 1 , Natalie Marie Petryk 1 , Ellen Shepherd 1 , Henry T Beaman 1 , Priya S Ganesh 1 , Katheryn S Dong 1 , Mary Beth B Monroe 1
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Uncontrolled hemorrhage is the leading cause of preventable death on the battlefield and results in ∼1.5 million deaths each year. The primary current treatment options are gauze and/or tourniquets, which are ineffective for up to 80% of wounds. Additionally, most hemostatic materials must be removed from the patient within <12 h, which limits their applicability in remote scenarios and can cause additional bleeding upon removal. Here, degradable shape memory polymer (SMP) foams were synthesized to overcome these limitations. SMP foams were modified with oxidatively labile ether groups and hydrolytically labile ester groups to degrade after implantation. Foam physical, thermal, and shape memory properties were assessed along with cytocompatibility and blood interactions. Degradation profiles were obtained in vitro in oxidative and hydrolytic media (3% H2O2 (oxidation) and 0.1 M NaOH (hydrolysis) at 37 °C). The resulting foams had tunable, clinically relevant degradation rates, with complete mass loss within 30–60 days. These SMP foams have potential to provide an easy-to-use, shape-filling hemostatic dressing that can be left in place during traumatic wound healing with future potential use in regenerative medicine applications.
中文翻译：
具有可调降解曲线的形状记忆聚合物泡沫
失控失血是战场上可预防死亡的主要原因，每年导致约 150 万人死亡。目前主要的治疗选择是纱布和/或止血带，这对高达 80% 的伤口无效。此外，大多数止血材料必须在<12 id=104>2 O 2 （氧化）和0.1 M NaOH（水解）（37°C）内从患者体内去除。由此产生的泡沫具有可调节的、临床相关的降解率，在 30-60 天内完全损失质量。这些 SMP 泡沫有潜力提供一种易于使用、可填充形状的止血敷料，可以在创伤性伤口愈合过程中留在原处，并在未来的再生医学应用中发挥潜在作用。
更新日期：2021-09-20
中文翻译：
具有可调降解曲线的形状记忆聚合物泡沫
失控失血是战场上可预防死亡的主要原因，每年导致约 150 万人死亡。目前主要的治疗选择是纱布和/或止血带，这对高达 80% 的伤口无效。此外，大多数止血材料必须在<12 id=104>2 O 2 （氧化）和0.1 M NaOH（水解）（37°C）内从患者体内去除。由此产生的泡沫具有可调节的、临床相关的降解率，在 30-60 天内完全损失质量。这些 SMP 泡沫有潜力提供一种易于使用、可填充形状的止血敷料，可以在创伤性伤口愈合过程中留在原处，并在未来的再生医学应用中发挥潜在作用。
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